Autophagy machinery as exploited by viruses

Münz, Christian; Campbell, Grant R; Esclatine, Audrey; Faure, Mathias; Labonté, Patrick ORCID: https://orcid.org/0000-0001-7262-3125; Lussignol, Marion; Orvedahl, Anthony; Altan-Bonnet, Nihal; Bartenschlager, Ralf; Beale, Rupert; Cirone, Mara; Espert, Lucille; Jung, Jae; Leib, David; Reggiori, Fulvio; Sanyal, Sumana; Spector, Stephen A; Thiel, Volker; Viret, Christophe; Wei, Yu; Wileman, Thomas et Wodrich, Harald (2025). Autophagy machinery as exploited by viruses Autophagy Reports , vol. 4 , nº 1. pp. 1-38. DOI: 10.1080/27694127.2025.2464986.

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Résumé

Viruses adapt and modulate cellular pathways to allow their replication in host cells. The catabolic pathway of macroautophagy, for simplicity referred to as autophagy, is no exception. In this review, we discuss anti-viral functions of both autophagy and select components of the autophagy machinery, and how viruses have evaded them. Some viruses use the membrane remodeling ability of the autophagy machinery to build their replication compartments in the cytosol or efficiently egress from cells in a non-lytic fashion. Some of the autophagy machinery components and their remodeled membranes can even be found in viral particles as envelopes or single membranes around virus packages that protect them during spreading and transmission. Therefore, studies on autophagy regulation by viral infections can reveal functions of the autophagy machinery beyond lysosomal degradation of cytosolic constituents. Furthermore, they can also pinpoint molecular interactions with which the autophagy machinery can most efficiently be manipulated, and this may be relevant to develop effective disease treatments based on autophagy modulation.

Type de document:	Article
Informations complémentaires:	document: 2464986 Funding P.L. was the recipient of a Discovery grant from the Natural Sciences and Engineering Research Council of Canada (NSERC), RGPIN06932
Mots-clés libres:	Endosomal damage; interferon; replication organelle; secretory autophagy; virophagy
Centre:	Centre INRS-Institut Armand Frappier
Date de dépôt:	07 juill. 2025 18:51
Dernière modification:	07 juill. 2025 18:51
URI:	https://espace.inrs.ca/id/eprint/16450

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