Promising animal models for amyotrophic lateral sclerosis drug discovery: a comprehensive update

Lescouzères, Léa et Patten, Shunmoogum A. ORCID: https://orcid.org/0000-0002-2782-3547 (2024). Promising animal models for amyotrophic lateral sclerosis drug discovery: a comprehensive update Expert Opinion on Drug Discovery . pp. 1-21. DOI: 10.1080/17460441.2024.2387791.

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Résumé

INTRODUCTION: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the progressive loss of motor neurons. Several animal models have been generated to understand ALS pathogenesis. They have provided valuable insight into disease mechanisms and the development of therapeutic strategies.

AREAS COVERED: In this review, the authors provide a concise overview of simple genetic model organisms, including C. elegans, Drosophila, zebrafish, and mouse genetic models that have been generated to study ALS. They emphasize the benefits of each model and their application in translational research for discovering new chemicals, gene therapy approaches, and antibody-based strategies for treating ALS.

EXPERT OPINION: Significant progress is being made in identifying new therapeutic targets for ALS. This progress is being enabled by promising animal models of the disease using increasingly effective genetic and pharmacological strategies. There are still challenges to be overcome in order to achieve improved success rates for translating drugs from animal models to clinics for treating ALS. Several promising future directions include the establishment of novel preclinical protocol standards, as well as the combination of animal models with human induced pluripotent stem cells (iPSCs).

Type de document:	Article
Mots-clés libres:	-
Centre:	Centre INRS-Institut Armand Frappier
Date de dépôt:	11 août 2024 07:55
Dernière modification:	11 août 2024 07:55
URI:	https://espace.inrs.ca/id/eprint/15931

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