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Enzyme catalysis under pressure

Doucet, Nicolas (2019). Enzyme catalysis under pressure Nature Catalysis , vol. 2 . p. 646-647. DOI: 10.1038/s41929-019-0326-3. (Sous Presse)

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Résumé

A strategy using pressure was devised to structurally identify conformational transitions in protein ensembles, allowing the rational prediction of mutations that induce pressure-driven enzyme activation. These results highlight the power of flexibility–function analyses in protein engineering design and applications.

Type de document: Article
Mots-clés libres: Biocatalysis; Computational biophysics; Enzyme mechanisms; Solution-state NMR; Transferases
Centre: Centre INRS-Institut Armand Frappier
Date de dépôt: 11 janv. 2020 15:35
Dernière modification: 11 janv. 2020 15:35
URI: http://espace.inrs.ca/id/eprint/8611

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