Doucet, Nicolas 
ORCID: https://orcid.org/0000-0002-1952-9380
(2019).
Enzyme catalysis under pressure
Nature Catalysis
, vol. 2
.
pp. 646-647.
DOI: 10.1038/s41929-019-0326-3.
Résumé
A strategy using pressure was devised to structurally identify conformational transitions in protein ensembles, allowing the rational prediction of mutations that induce pressure-driven enzyme activation. These results highlight the power of flexibility–function analyses in protein engineering design and applications.
| Type de document: | Article |
|---|---|
| Mots-clés libres: | Biocatalysis; Computational biophysics; Enzyme mechanisms; Solution-state NMR; Transferases |
| Centre: | Centre INRS-Institut Armand Frappier |
| Date de dépôt: | 11 janv. 2020 15:35 |
| Dernière modification: | 15 févr. 2022 15:34 |
| URI: | https://espace.inrs.ca/id/eprint/8611 |
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