Silva-Barrios, Sasha et Stäger, Simona 
ORCID: https://orcid.org/0000-0001-5508-9565
(2019).
Hypergammaglobulinemia sustains the development of regulatory responses during chronic Leishmania donovani infection in mice.
European Journal of Immunology
, vol. 49
.
pp. 1082-1091.
DOI: 10.1002/eji.201847917.
Résumé
Visceral leishmanisiais, a chornic, potentially fatal disease, is characterized by high production of low-affinity antibodies. In humans, hypergammaglobulinemia is prediction of disease progression. Nevertheless, the contribution of hypermutated and/or class-switched immunoglobulins to disease pathogenesis has never been studied. Using Aicda-/- mice and the experimental model of Leishmania donovani infection, we demonstrate that the absence of hypermutated and/or class-switched antibodies was associated with increased resistance to disease, stronger protective Th1 responses and a lower frequency of regulatory IFNγ+ IL-10+ CD4 T cells. Interestingly, stronger Th1 responses and the absence of IFNγ+ IL-10+ CD4 T cells during chronic infection in infected Aicda-/- mice was not caused by a T cell intrinsic effect of AID, but by changes in the cytokine environment during chronic disease. Indeed TNF, IL-10 and IFN-ß expressions were only upregulated in the presence of hypermutated, class-switched antibodies and hypergammaglobulinemia at later stages of infection. Taken together, our results suggest that hypergammaglobulinemia sustains inhibitory responses during chronic visceral leishmaniasis.
| Type de document: | Article |
|---|---|
| Mots-clés libres: | AID; Leishmania donovani; T helper cells; hypergammaglobulinemia; regulatory T cells |
| Centre: | Centre INRS-Institut Armand Frappier |
| Date de dépôt: | 28 janv. 2020 21:15 |
| Dernière modification: | 16 févr. 2022 15:05 |
| URI: | https://espace.inrs.ca/id/eprint/8215 |
Gestion Actions (Identification requise)
 |
Modifier la notice |