Suarthana, Eva; Achore, Meshack; Taghiakbari, Mahsa; Lemiere, Catherine; Rhazia, Mounia S.; Gautrin, Denyse et El-Zein, Mariam . Long-term respiratory effects of exposure to welding fumes: Quebec apprentice cohort study In: 28th ERS International Congress 2018, 15-19 September 2018, Paris, France.
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Background: Welding fumes are known to cause respiratory health problems.
Aims and Objectives: We evaluated the long-term respiratory effects of exposure to welding fumes.
Methods: Inception cohorts of welding, plumbing and heating apprentices were prospectively contacted 7-17 years post-apprenticeship. Questionnaires, spirometry and non-specific bronchial hyper-responsiveness (NSBHR) test were repeatedly administered. Long-term evaluation was done in 90 of 330 former apprentices at the Hôpital du Sacré-Cœur de Montréal between 2013 and 2017. Characteristics at the end of apprenticeship were comparable between subjects who participated and who did not. The risk of work-related lower respiratory symptoms suggestive of occupational asthma (OA) and excessive lung function decline given continued post-apprenticeship exposure to welding fumes was estimated with Cox regression.
Results: Incident symptoms suggestive of OA was found in 25.8% subjects and excessive lung function decline was observed in 12.7% subjects. Based on an asthma-specific job exposure matrix, post-apprenticeship exposure to welding fumes was significantly associated with a reduced risk of developing symptoms suggestive of OA (hazards ratio (HR) 0.24; 95% confidence interval (CI) 0.06-0.91). The association persisted after adjusting for obesity, self-reported wheezing, and NSBHR at the end of apprenticeship (HR 0.22; 95% CI 0.05-1.0). A reduced risk of developing excessive lung function decline was also found, but the association was not significant (HR 0.63; 95% CI 0.07-5.3).
Conclusions: Continued post-apprenticeship exposure to welding fumes was not associated with an increased risk of developing long-term respiratory outcomes.
| Type de document: | Document issu d'une conférence ou d'un atelier |
|---|---|
| Informations complémentaires: | European Respiratory Journal 2018 52: Suppl. 62, PA4526 DOI: 10.1183/13993003.congress-2018 Affiche scientifique |
| Mots-clés libres: | - |
| Centre: | Centre INRS-Institut Armand Frappier |
| Date de dépôt: | 20 nov. 2019 20:54 |
| Dernière modification: | 20 nov. 2019 20:54 |
| URI: | https://espace.inrs.ca/id/eprint/8180 |
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