Porcheron, Gaëlle; Schouler, Catherine et Dozois, Charles M. 
ORCID: https://orcid.org/0000-0003-4832-3936
(2016).
Survival games at the dinner table: Regulation of Enterobacterial virulence through nutrient sensing and acquisition
Current Opinion in Microbiology
, vol. 30
.
pp. 98-106.
DOI: 10.1016/j.mib.2016.01.008.
Résumé
The ability of bacterial pathogens to colonize specific host niches is largely dependent on acquisition of essential metabolites and co-factors for growth and sensing and adapting in response to specific environmental cues. Nutrient availability in host environments is strongly influenced by host physiology and immunity, diet, and competition with other members of the host microbiota. Rapid adaptation to environmental cues and nutrient availability is a hallmark of bacterial fitness and virulence. This adaptability requires complex regulatory networks that tightly link sensing of nutrient availability to expression of virulence genes accordingly. This review focuses on recent findings highlighting the ability of bacterial pathogens to compete for nutrient acquisition in the host-microbiota environment, and emphasizes key aspects mediating the multi-tiered regulatory cascades that coordinately control nutrient sensing and expression of virulence genes in pathogenic Enterobacteria.
| Type de document: | Article |
|---|---|
| Mots-clés libres: | competition; diet; Enterobacteriaceae; gene expression; immunity; metabolite; microflora; nutrient; nutrient availability; physiology; virulence |
| Centre: | Centre INRS-Institut Armand Frappier |
| Date de dépôt: | 15 mai 2017 17:53 |
| Dernière modification: | 21 févr. 2022 20:07 |
| URI: | https://espace.inrs.ca/id/eprint/4611 |
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