Ozone treatment prevents the toxicity of an environmental mixture of estrogens on rat fetal testicular development

Lassonde, Guylaine; Nasuhoglu, Deniz; Pan, Jun Feng; Gaye, Bintou; Yargeau, Viviane et Delbès, Géraldine ORCID: https://orcid.org/0000-0002-9169-1075 (2015). Ozone treatment prevents the toxicity of an environmental mixture of estrogens on rat fetal testicular development Reproductive Toxicology , vol. 58 . pp. 85-92. DOI: 10.1016/j.reprotox.2015.09.001.

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Résumé

The symbols and special characters used in the original abstract could not be transcribed due to technical problems. Please use the PDF version to read the abstract. Effluents from wastewater treatment plants contain a mixture of estrogens (MIX: 17beta-estradiol: E2, estrone: E1, estriol: E3 and 17alpha-ethinylestradiol EE2). High doses of estrogens have been shown to negatively impact fetal testicular development, but the impact of low doses of estrogens in mixture have yet to be elucidated. Using an organ culture system in which embryonic 15.5 day-old rat testes were grown ex vivo, we showed that exposure to the MIX at environmentally relevant concentrations reduces testis growth. No effect was observed on testosterone secretion, but we quantified a significant decrease in the number of Sertoli cells and gonocytes because of higher rates of apoptosis. As ozone (O3) can be used as a disinfectant during wastewater treatment, we confirmed by HPLC-MS analysis that it removes the four parent compounds. Interestingly, the negative effects of the MIX were not observed when testes were exposed to the MIX treated with O3.

Type de document:	Article
Informations complémentaires:	Résumé avec symboles
Mots-clés libres:	Estrogen; Fetal testis; Low doses; Mixtures; Organ culture; Ozone; Water treatment
Centre:	Centre INRS-Institut Armand Frappier
Date de dépôt:	16 mai 2017 20:01
Dernière modification:	08 juin 2023 17:55
URI:	https://espace.inrs.ca/id/eprint/3214

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