Arango Duque, Guillermo et Descoteaux, Albert 
ORCID: https://orcid.org/0000-0002-0633-5309
(2015).
Leishmania survival in the macrophage: where the ends justify the means
Current Opinion in Microbiology
, vol. 26
.
pp. 32-40.
DOI: 10.1016/j.mib.2015.04.007.
Résumé
Macrophages are cells of the immune system that mediate processes ranging from phagocytosis to tissue homeostasis. Leishmania has evolved ingenious ways to adapt to life in the macrophage. The GP63 metalloprotease, which disables key microbicidal pathways, has recently been found to disrupt processes ranging from antigen cross-presentation to nuclear pore dynamics. New studies have also revealed that Leishmania sabotages key metabolic and signaling pathways to fuel parasite growth. Leishmania has also been found to induce DNA methylation to turn off genes controlling microbicidal pathways. These novel findings highlight the multipronged attack employed by Leishmania to subvert macrophage function.
| Type de document: | Article |
|---|---|
| Mots-clés libres: | - |
| Centre: | Centre INRS-Institut Armand Frappier |
| Date de dépôt: | 10 mai 2017 20:04 |
| Dernière modification: | 21 févr. 2022 19:53 |
| URI: | https://espace.inrs.ca/id/eprint/3144 |
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