Yousefi, Mitra et Duplay, Pascale (2013). CD28 controls the development of innate-like CD8+ T cells by promoting the functional maturation of NKT cells European Journal of Immunology , vol. 43 , nº 11. pp. 3017-3027. DOI: 10.1002/eji.201343627.
Ce document n'est pas hébergé sur EspaceINRS.Résumé
La transcription des symboles et des caractères spéciaux utilisés dans la version originale de ce résumé n’a pas été possible en raison de limitations techniques. La version correcte de ce résumé peut être lue en PDF. The symbols and special characters used in the original abstract could not be transcribed due to technical problems. Please use the PDF version to read the abstract. NK T cells(NKT cells) share functional characteristics and homing properties that are distinct from conventional T cells. In this study, we investigated the contribution of CD28 in the functional development of γδ NKT and αβ NKT cells in mice. We show that CD28 promotes the thymic maturation of promyelocytic leukemia zinc finger+ IL-4+ NKT cells and upregulation of LFA-1 expression on NKT cells. We demonstrate that the developmental defect of γδ NKT cells in CD28-deficient mice is cell autonomous. Moreover, we show in both wild-type C57BL/6 mice and in downstream of tyrosine kinase-1 transgenic mice, a mouse model with increased numbers of γδ NKT cells, that CD28-mediated regulation of thymic IL-4+ NKT cells promotes the differentiation of eomesodermin+ CD44high innate-like CD8+ T cells. These findings reveal a previously unappreciated mechanism by which CD28 controls NKT-cell homeostasis and the size of the innate-like CD8+ T-cell pool.
| Type de document: | Article |
|---|---|
| Mots-clés libres: | CD28; Innate-like CD8 T cells; NKT cells; PLZF; Thymocyte development |
| Centre: | Centre INRS-Institut Armand Frappier |
| Date de dépôt: | 21 sept. 2016 19:42 |
| Dernière modification: | 08 juin 2023 17:48 |
| URI: | https://espace.inrs.ca/id/eprint/2995 |
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