Heidari-Kharaji, Maryam i; Rodrigues, Priscilla et Petersen, Christina (2025). Solid Lipid Nanoparticles Encapsulated With Paromomycin: An Effective Oral Formulation Against Leishmania major in Mouse Model Parasite Immunology , vol. 47 , nº 2:e70002. pp. 1-10. DOI: 10.1111/pim.70002.
Ce document n'est pas hébergé sur EspaceINRS.Résumé
Leishmaniasis is a disease caused by protozoan parasites of the genus Leishmania. The treatment of intracellular infections
such as leishmaniasis is often challenging due to limited drug access to infected cells and the development of drug resistance.
Therefore, the development of new antileishmanial compounds is essential. Paromomycin sulphate (PM) has shown promise as
an antileishmanial drug, and one way to enhance its effectiveness is through appropriate delivery systems. Solid lipid nanoparticles (SLN) are being explored as a potential delivery system for PM, as they offer advantages over other colloidal carriers. In a recent study, PM was loaded into solid lipid nanoparticles (PM-SLN) and its oral effectiveness was evaluated in treating Leishmania
(L.) major-infected mice. The study measured footpad swelling, quantified parasite load through real-time PCR and assessed
levels of cytokines such as interleukin-4 (IL-4) and gamma interferon (IFN-c), nitric oxide (NO) and Arginase (ARG). Overall,
the study demonstrated that oral administration of the PM-SLN formulation is safe and effective in treating leishmaniasis. The
SLN in the PM-SLN compound improved the killing of parasites by PM and stimulated a Th1 immune response, indicating its
potential as a treatment for leishmaniasis.
| Type de document: | Article |
|---|---|
| Mots-clés libres: | cutaneous leishmaniasis; cytokine; drug delivery system; paromomycin sulphate; solid lipid nanoparticle; therapy |
| Centre: | Centre INRS-Institut Armand Frappier |
| Date de dépôt: | 03 mars 2025 05:28 |
| Dernière modification: | 03 mars 2025 05:28 |
| URI: | https://espace.inrs.ca/id/eprint/16345 |
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