Lopez, Guillaume; Adda-Bouchard, Yasmine; Laulhe, Xavier; Chamberlain, Gabriel; Bourguignon, Léa; Charpentier, Tania; Cyr, Daniel G. 
ORCID: https://orcid.org/0000-0002-6566-783X et Lamarre, Alain ORCID: https://orcid.org/0000-0002-7913-871X
(2025).
Short-term oral exposure to nanoplastics does not significantly impact the antiviral immune response of the mouse
Journal of Hazardous Materials
, vol. 488
, nº 137316.
pp. 1-15.
DOI: 10.1016/j.jhazmat.2025.137316.
Résumé
The increasing prevalence of nanoplastics (NPs) in the environment, particularly polystyrene (PS) nanoparticles, raises concerns regarding their potential impact on human and animal health. Given their small size, NPs can cross biological barriers and accumulate in organs, including those critical for immune functions. This study investigates the effects of short-term oral exposure to 100 and 500 nm PS NPs on the adaptive immune responses during viral infections in vivo, using vesicular stomatitis virus (VSV) and lymphocytic choriomeningitis virus (LCMV) as models. Male and female C57BL/6 mice were orally exposed to PS NP for a period of 28 days, during which they were infected with either VSV or LCMV to study the humoral and cellular responses, respectively. The humoral responses were assessed by measuring total and VSV-specific antibody levels, and splenic immune populations. T cell phenotypes, activation, exhaustion and functionality towards LCMV epitopes were studied as readouts of the cellular responses. Our results demonstrate that short-term NP exposure does not significantly affect the generation or neutralizing capacity of antibodies against VSV, nor the cellular responses directed against LCMV. These findings indicate that, under these conditions, PS NP exposure does not significantly compromise the adaptive immune responses during viral infections, underscoring the value of in vivo models.
| Type de document: | Article |
|---|---|
| Mots-clés libres: | Adaptive immunity; Inflammation; Mouse in vivo studies; Polystyrene nanoplastics; Viral infections |
| Centre: | Centre INRS-Institut Armand Frappier |
| Date de dépôt: | 27 janv. 2025 22:49 |
| Dernière modification: | 27 janv. 2025 22:49 |
| URI: | https://espace.inrs.ca/id/eprint/16278 |
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