UL24 herpesvirus determinants of pathogenesis: Roles in virus-host interactions

Pearson, Angela ORCID: https://orcid.org/0000-0002-5997-2846 et Bouhamar, Amel (2025). UL24 herpesvirus determinants of pathogenesis: Roles in virus-host interactions Virology , vol. 603 , nº 110376. pp. 1-9. DOI: 10.1016/j.virol.2024.110376.

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Résumé

Members of the UL24 herpesvirus gene family are determinants of pathogenesis. The gene is widely conserved across the Orthoherpesviridae family, also commonly referred to as Herpesviridae. In this review, the impact of UL24 homologs on pathogenesis as studied with different model systems is presented, as well as mechanistic aspects related to the different roles of UL24 proteins in virus-host cell interactions. The targeting of UL24 for the development of therapeutic applications is also discussed.

Type de document:	Article
Mots-clés libres:	Determinant of pathogenesis; Herpesvirus; Innate immunity; Nucleolus; PD-D/EXK endonuclease motif; Syncytia; UL24
Centre:	Centre INRS-Institut Armand Frappier
Date de dépôt:	24 janv. 2025 15:15
Dernière modification:	24 janv. 2025 15:15
URI:	https://espace.inrs.ca/id/eprint/16275

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