Todkar, Kiran; Amari, Lydia et Germain, Marc (2024). Mitochondria-derived vesicles: from quality control to inflammation and extracellular vesicles In: Mitophagy in Health and Disease: Mechanisms, Health Implications, and Therapeutic Opportunities. Academic Press, Cambridge, MA, pp. 103-118.
Ce document n'est pas hébergé sur EspaceINRS.Résumé
Mitochondria perform key cellular processes, from the production of ATP and essential metabolites to the control of cell fate. Mitochondrial dysfunction thus has a severe impact on homeostasis, both at the cellular level and for the organism. Several mitochondria quality control mechanisms promote the clearance of damaged mitochondrial components to maintain the proper function of these organelles. Among these, mitochondria-derived vesicles promote the removal of large protein complexes that are damaged. However, their roles extend beyond this, as they also play a key role in not only mitochondrial bioenergetics but also in inflammation and incorporation of mitochondrial components into extracellular vesicles (EVs). The mitochondrial content within EVs can then be transferred to distant cells to modulate bioenergetics and inflammation.
| Type de document: | Chapitre de livre |
|---|---|
| Mots-clés libres: | - |
| Centre: | Centre INRS-Institut Armand Frappier |
| Date de dépôt: | 06 janv. 2025 05:45 |
| Dernière modification: | 06 janv. 2025 05:45 |
| URI: | https://espace.inrs.ca/id/eprint/16245 |
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