Gestational urinary concentrations of glyphosate and aminomethylphosphonic acid in relation to preterm birth: the MIREC study

Ashley-Martin, Jillian; Marro, Leonora; Owen, James; Borghese, Michael M; Arbuckle, Tye E; Bouchard, Maryse F. ORCID: https://orcid.org/0000-0001-6246-4802; Lanphear, Bruce; Walker, Mark; Foster, Warren G et Fisher, Mandy (2024). Gestational urinary concentrations of glyphosate and aminomethylphosphonic acid in relation to preterm birth: the MIREC study Journal of Exposure Science and Environmental Epidemiology , vol. ahead . DOI: 10.1038/s41370-024-00702-w. (Sous Presse)

Prévisualisation

PDF - Version publiée Disponible sous licence Creative Commons Attribution. Télécharger (464kB) | Prévisualisation

Résumé

BACKGROUND:

Few high-quality studies have evaluated associations between urinary glyphosate or its environmental degradate (aminomethylphosphonic acid (AMPA)] and preterm birth (PTB).

OBJECTIVES:

To quantify associations between urinary glyphosate and AMPA and preterm birth in the pan-Canadian Maternal-Infant Research on Environmental Chemicals (MIREC) study and determine if associations differ by fetal sex.

METHODS:

We measured first trimester urinary glyphosate and AMPA concentrations in MIREC participants who were recruited between 2008-2011 from 10 Canadian cities. Of the 1880 participants whose first trimester urine samples were analyzed for glyphosate or AMPA, 1765 delivered a singleton, live birth. Our primary outcome was preterm birth (PTB) defined as births occurring between 20 and < 37 weeks. Secondary outcomes were spontaneous preterm births (sPTB) and gestational age. We modelled the hazard of PTB and sPTB using discrete time survival analysis with multivariable logistic regression to calculate odds ratios (OR). We used multivariable linear regression models to quantify associations between analytes and gestational age. To assess effect modification by fetal sex, we stratified all models and calculated interaction terms. In the logistic regressions models we additionally calculated the relative excess risk due to interaction.

RESULTS:

Six percent (n = 106) of the study population delivered preterm, and 4.7% (n = 83) had a spontaneous preterm birth. Median specific-gravity standardized concentrations of glyphosate and AMPA were 0.25 and 0.21 µg/L. Associations between both glyphosate or AMPA and PTB, sPTB, and gestational age centered around the null value. The adjusted ORs of PTB for each doubling of glyphosate and AMPA concentrations were 0.98 (95% CI: 0.94, 1.03) and 0.99 (95% CI: 0.92, 1.06) respectively. We observed no evidence of differences by fetal sex.

CONCLUSIONS:

In this Canadian pregnancy cohort, neither glyphosate nor AMPA urinary concentrations was associated with PTB or reduced gestational length.

Type de document:	Article
Mots-clés libres:	Glyphosate; AMPA; preterm birth; pregnancy; biomonitoring; cohort
Centre:	Centre INRS-Institut Armand Frappier
Date de dépôt:	23 sept. 2024 19:28
Dernière modification:	23 sept. 2024 19:28
URI:	https://espace.inrs.ca/id/eprint/15974

Gestion Actions (Identification requise)

Modifier la notice