Kouam, Leslie; Nicolau, Belinda; Rousseau, Marie-Claude ORCID: https://orcid.org/0000-0001-5215-8086; Richard, Hugues; Corsenac, Philippe et Parent, Marie-Élise
ORCID: https://orcid.org/0000-0002-4196-3773
(2024).
2D:4D digit ratio as a potential marker for prostate cancer risk
Cancer Epidemiology
, vol. 92
, nº 102635.
pp. 1-5.
DOI: 10.1016/j.canep.2024.102635.
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Résumé
Background: The second-to-fourth digit ratio (2D:4D) is thought to reflect prenatal exposure to sex steroids. We investigated the relationship between 2D:4D and odds of prostate cancer.
Method: Data were collected in PROtEuS, a population-based case-control study conducted in Montréal, Canada (2005–2012), including 1931 incident prostate cancer cases aged < 76 years and 1994 population controls. In-person interviews elicited information on potential risk factors. Digit lengths were measured by interviewers applying a standard protocol. Odds ratios (OR) and 95 % confidence intervals (CI) were estimated using unconditional logistic regression adjusting for potential confounders.
Results: The OR of prostate cancer for a standard deviation increase in 2D:4D was 0.91 (95 % CI: 0.85–0.98). For less and more aggressive cancers, ORs were 0.93 (95 % CI: 0.87–1.00) and 0.85 (95 % CI: 0.77–0.93), respectively. There was an interaction with ancestry (p=0.04), whereas the OR among men of African descent was 1.23 (95 % CI: 0.96–1.57, based on 128 cases).
Conclusion: Findings suggest an inverse association between 2D:4D and odds of overall prostate cancer, more pronounced for aggressive cancers. This supports the notion that high levels of testosterone in utero, estimated by a low 2D:4D ratio, are associated with a higher risk of prostate cancer. Contrastingly, a high digit ratio was associated with greater cancer odds among participants of African descent. Upon replication, 2D:4D could prove to be an easily measured marker of prostate cancer risk.
Type de document: | Article |
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Mots-clés libres: | 2D:4D; Case-control; Digit ratio; In utero; Prostate cancer; Sex hormones |
Centre: | Centre INRS-Institut Armand Frappier |
Date de dépôt: | 04 août 2024 04:15 |
Dernière modification: | 04 août 2024 04:15 |
URI: | https://espace.inrs.ca/id/eprint/15921 |
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