2D:4D digit ratio as a potential marker for prostate cancer risk

Kouam, Leslie; Nicolau, Belinda; Rousseau, Marie-Claude ORCID: https://orcid.org/0000-0001-5215-8086; Richard, Hugues; Corsenac, Philippe et Parent, Marie-Élise ORCID: https://orcid.org/0000-0002-4196-3773 (2024). 2D:4D digit ratio as a potential marker for prostate cancer risk Cancer Epidemiology , vol. 92 , nº 102635. pp. 1-5. DOI: 10.1016/j.canep.2024.102635.

Prévisualisation

PDF - Version publiée Disponible sous licence Creative Commons Attribution. Télécharger (399kB) | Prévisualisation

Résumé

Background: The second-to-fourth digit ratio (2D:4D) is thought to reflect prenatal exposure to sex steroids. We investigated the relationship between 2D:4D and odds of prostate cancer.

Method: Data were collected in PROtEuS, a population-based case-control study conducted in Montréal, Canada (2005–2012), including 1931 incident prostate cancer cases aged < 76 years and 1994 population controls. In-person interviews elicited information on potential risk factors. Digit lengths were measured by interviewers applying a standard protocol. Odds ratios (OR) and 95 % confidence intervals (CI) were estimated using unconditional logistic regression adjusting for potential confounders.

Results: The OR of prostate cancer for a standard deviation increase in 2D:4D was 0.91 (95 % CI: 0.85–0.98). For less and more aggressive cancers, ORs were 0.93 (95 % CI: 0.87–1.00) and 0.85 (95 % CI: 0.77–0.93), respectively. There was an interaction with ancestry (p=0.04), whereas the OR among men of African descent was 1.23 (95 % CI: 0.96–1.57, based on 128 cases).

Conclusion: Findings suggest an inverse association between 2D:4D and odds of overall prostate cancer, more pronounced for aggressive cancers. This supports the notion that high levels of testosterone in utero, estimated by a low 2D:4D ratio, are associated with a higher risk of prostate cancer. Contrastingly, a high digit ratio was associated with greater cancer odds among participants of African descent. Upon replication, 2D:4D could prove to be an easily measured marker of prostate cancer risk.

Type de document:	Article
Mots-clés libres:	2D:4D; Case-control; Digit ratio; In utero; Prostate cancer; Sex hormones
Centre:	Centre INRS-Institut Armand Frappier
Date de dépôt:	04 août 2024 04:15
Dernière modification:	04 août 2024 04:15
URI:	https://espace.inrs.ca/id/eprint/15921

Gestion Actions (Identification requise)

Modifier la notice