Environmental and Nutritional Parameters Modulating Genetic Expression for Virulence Factors of Clostridioides difficile

Masset, Zoé; Gunaratnam, Sathursha; Millette, Mathieu; McFarland, Lynne V et Lacroix, Monique ORCID: https://orcid.org/0000-0002-2042-4033 (2024). Environmental and Nutritional Parameters Modulating Genetic Expression for Virulence Factors of Clostridioides difficile Antibiotics , vol. 13 , nº 4:365. pp. 1-14. DOI: 10.3390/antibiotics13040365.

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Résumé

Clostridioides difficile infections (CDIs) continue to be a persistent healthcare concern despite newer antibiotic treatments, enhanced infection control practices, and preventive strategies focused on restoring the protective intestinal microbial barrier. Recent strides in gene sequencing research have identified many genes regulating diverse virulence factors for CDIs. These genes may be over- or under-expressed when triggered by various environmental and nutritional factors. The aims of this paper are to review the important genes involved in C. difficile pathogenesis and to identify modifiable environmental, nutritional, and other factors that may trigger the expression of these genes and thus offer new strategies to prevent CDIs.

Type de document:	Article
Mots-clés libres:	CDI; Clostridioides difficile; Antibiotics; Environmental factors; Gene expression; Probiotics; Virulence
Centre:	Centre INRS-Institut Armand Frappier
Date de dépôt:	29 avr. 2024 15:24
Dernière modification:	29 avr. 2024 15:24
URI:	https://espace.inrs.ca/id/eprint/15628

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