Vida, Stephen; Pintos, Javier; Parent, Marie-Élise 
ORCID: https://orcid.org/0000-0002-4196-3773; Lavoué, Jerome et Siemiatycki, Jack
(2010).
Occupational exposure to silica and lung cancer: Pooled analysis of two case-control studies in Montreal, Canada
Cancer Epidemiology Biomarkers & Prevention
, vol. 19
, nº 6.
pp. 1602-1611.
DOI: 10.1158/1055-9965.EPI-10-0015.
Résumé
Background: Respirable crystalline silica is a highly prevalent occupational exposure and a recognized lung carcinogen. Most previous studies have focused on selected high-exposure occupational groups. This study examines the relationship between occupational exposure to silica and lung cancer in an occupationally diverse male population. Methods: Two large population-based case-control studies of lung cancer were conducted in Montreal, one in 1979-1986 (857 cases, 533 population controls, 1,349 cancer controls) and the second in 1996-2001 (738 cases and 899 controls). Interviews provided descriptive lifetime job histories, smoking histories, and other information. Industrial hygienists translated job histories into histories of exposure to a host of occupational substances, including silica. Relative risk was estimated, adjusting for several potential confounders, including smoking. Results: The odds ratio for substantial exposure to silica was 1.67 (95% confidence interval, 1.21-2.31) and for any exposure was 1.31 (95% confidence interval, 1.08-1.59). Joint effects between silica and smoking were between additive and multiplicative, perhaps closer to the latter. In this population, it is estimated that approximately 3% of lung cancers were attributable to substantial silica exposure. Conclusions: The carcinogenicity of inhaled crystalline silica was observed in a population with a wide variety of exposure circumstances. Impact: The finding of carcinogenicity across a wide range of occupations complements prior studies of specific high-exposure occupations. This suggests that the burden of cancer induced by silica may be much greater than previously thought.
| Type de document: | Article |
|---|---|
| Mots-clés libres: | - |
| Centre: | Centre INRS-Institut Armand Frappier |
| Date de dépôt: | 09 juill. 2024 14:46 |
| Dernière modification: | 09 juill. 2024 14:52 |
| URI: | https://espace.inrs.ca/id/eprint/15254 |
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