Viau, Mélanie; Lafond, Julie et Vaillancourt, Cathy 
ORCID: https://orcid.org/0000-0003-0543-6244
(2009).
Expression of placental serotonin transporter and 5-HT 2A receptor in normal and gestational diabetes mellitus pregnancies
Reproductive Biomedicine Online
, vol. 19
, nº 2.
pp. 207-215.
DOI: 10.1016/s1472-6483(10)60074-0.
Résumé
Recent studies reveal that serotonin (5-hydroxytryptamine, 5-HT) might play a role in the aetiology of gestational diabetes mellitus (GDM). The involvement of the serotonin transporter (SERT) and 5-HT(2A) receptor (5-HT(2A)R) in diabetes has also been suggested. However, placental SERT and 5-HT(2A)R have never been studied in GDM-complicated pregnancies. The aim of this study was to investigate the effect of GDM on the expression of both placental SERT and 5-HT(2A)R. First, immunohistochemical analysis demonstrated the presence of SERT and 5-HT(2A)R proteins in the villous trophoblast and the fetal capillary endothelium of normal term placental tissue. Protein and mRNA expression of SERT and 5-HT(2A)R in the villous cytotrophoblastic and syncytiotrophoblastic cells was further confirmed in primary culture. A significantly (P < 0.05) decreased expression of SERT mRNA (56.3%) and protein (79.7%), and 5-HT(2A)R mRNA (79.1%) and protein (29.1%) was observed in placental tissues from GDM compared with non-GDM pregnancies. These data suggest that SERT and 5-HT(2A)R might be implicated in the aetiology of GDM. Moreover, the presence of SERT and 5-HT(2A)R in villous trophoblastic cells argues in favour of an important role of serotonin in human placental function.
| Type de document: | Article |
|---|---|
| Mots-clés libres: | gestational diabetes mellitus; human; placenta; serotonin receptors; serotonin transporters; trophoblast |
| Centre: | Centre INRS-Institut Armand Frappier |
| Date de dépôt: | 21 juill. 2024 20:00 |
| Dernière modification: | 21 juill. 2024 20:00 |
| URI: | https://espace.inrs.ca/id/eprint/15253 |
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