Siddiqui, Sarah; Tarrab, Esther; Lamarre, Alain 
ORCID: https://orcid.org/0000-0002-7913-871X et Basta, Sameh
(2010).
Altered immunodominance hierarchies of CD8+ T cells in the spleen after infection at different sites is contingent on high virus inoculum
Microbes and Infection
, vol. 12
, nº 4.
pp. 324-330.
DOI: 10.1016/j.micinf.2010.01.004.
Résumé
Activated epitope-specific CD8+ T cells after virus infection can be organized into hierarchies (immunodominance), based on their ability to focus the response on few viral determinants. The mechanisms responsible for immunodominance can be multifactorial, with CD8+ T cells precursor frequencies recently highlighted as a key regulator. Employing the LCMV infection model, we demonstrate that the hierarchies were altered when comparing different sites of infection but only at high viral doses. These findings have significant implications when investigating immunity to viruses with different replication abilities that may override the influence of T cell precursor frequencies.
| Type de document: | Article |
|---|---|
| Mots-clés libres: | MHC Antigen; presentation/processing;Peptides/epitopes and viral antigens |
| Centre: | Centre INRS-Institut Armand Frappier |
| Date de dépôt: | 01 juill. 2024 03:53 |
| Dernière modification: | 01 juill. 2024 03:53 |
| URI: | https://espace.inrs.ca/id/eprint/15166 |
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