Nandi, Suvobroto; Shi, Bo; Perreault, Jonathan 
ORCID: https://orcid.org/0000-0003-4726-6319 et Gartenhaus, Ronald B.
(2006).
Characterization of the MCT-1 pseudogene: identification and implication of its location in a highly amplified region of chromosome 20
Biochimica et Biophysica Acta
, vol. 1759
, nº 5.
pp. 234-239.
DOI: 10.1016/j.bbaexp.2006.05.003.
Résumé
The MCT-1 oncogene was initially identified as an amplified gene on chromosome Xq22-24 in a T-cell lymphoma. MCT-1 is over-expressed in a subset of diffuse large B-cell lymphoma (DLBCL), a common form of Non-Hodgkin's Lymphoma (NHL). We have identified a pseudogene for MCT-1 (PsiMCT-1) that is located on chromosome 20q11.2, a region within an amplicon containing several important genes frequently amplified in certain breast and ovarian cancers. Genomic analysis revealed that PsiMCT-1 is a processed pseudogene. Interestingly, both MCT-1 and its pseudogene are located on regions of the genome that are frequently amplified in several different human malignancies. MCT-1 is the oldest known oncogene and its insertion as a pseudogene occurred at a later time point in evolution. Existence of PsiMCT-1 should be considered when analyzing genomic amplification and or expression of MCT-1. Analysis of MCT-1 and PsiMCT-1 might provide clues to cancer genes and their evolution across species.
| Type de document: | Article |
|---|---|
| Mots-clés libres: | Lymphoma; Pseudogene; MCT-1 oncogene; Gene amplification |
| Centre: | Centre INRS-Institut Armand Frappier |
| Date de dépôt: | 04 nov. 2024 20:47 |
| Dernière modification: | 04 nov. 2024 20:47 |
| URI: | https://espace.inrs.ca/id/eprint/14991 |
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