Martinic, Marianne M.; Rülicke, Thomas; Althage, Alana; Odermatt, Bernhard; Höchli, Matthias; Lamarre, Alain 
ORCID: https://orcid.org/0000-0002-7913-871X; Dumrese, Tilman; Speiser, Daniel E.; Kyburz, Diego; Hengartner, Hans et Zinkernagel, Rolf M.
(2003).
Efficient T cell repertoire selection in tetraparental chimeric mice independent of thymic epithelial MHC
Proceedings of the National Academy of Sciences of the United States of America
, vol. 100
, nº 4.
pp. 1861-1866.
DOI: 10.1073/pnas.252641399.
Résumé
Nonthymic epithelial cells were compared with thymic epithelial cells for their role in T cell repertoire selection. Tetraparental aggregation chimeras were generated from T and B cell-deficient mice (H-2(d) SCID or H-2(b) Rag-/-) and thymus-deficient nude mice (H-2(b) or H-2(d)). These tetraparental mice showed primary protective CD8(+) T cell responses, after lymphocytic choriomeningitis virus infection, that were peptide-specifically restricted to either thymic or nonthymic epithelial MHC at comparable levels. These chimeras also mounted neutralizing IgG responses dependent on cognate CD4(+) T helper cell activity restricted to nonthymic epithelial MHC. Therefore, in contrast to earlier results with irradiation or thymus chimeras, these relatively undisturbed tetraparental mice reveal that the MHC of nonthymic epithelial cells efficiently selects a functional T cell repertoire.
| Type de document: | Article |
|---|---|
| Mots-clés libres: | - |
| Centre: | Centre INRS-Institut Armand Frappier |
| Date de dépôt: | 26 déc. 2024 15:11 |
| Dernière modification: | 26 déc. 2024 15:11 |
| URI: | https://espace.inrs.ca/id/eprint/14949 |
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