Macpherson, Andrew J; Lamarre, Alain 
ORCID: https://orcid.org/0000-0002-7913-871X; McCoy, Kathy; Harriman, Gregory R.; Odermatt, Bernhard; Dougan, Gordon; Hengartner, Hans et Zinkernagel, Rolf M
(2001).
IgA production without mu or delta chain expression in developing B cells
Nature Immunology
, vol. 2
, nº 7.
pp. 625-631.
DOI: 10.1038/89775.
Résumé
Surface, membrane-bound, immunoglobulin M (IgM) or IgD expression early in B cell ontogeny is considered essential for the differentiation of antibody-producing cells in mammals; only in IgM+ B cells is the heavy chain locus rearranged to express antibodies of other classes. We show here that IgA is selectively expressed in muMT mice, which lack IgM or IgD expression and have a pro-B cell developmental block. muMT IgA binds proteins of commensal intestinal bacteria and is weakly induced by Salmonella infection, although not through conventional immunization. This muMT IgA pathway requires extrasplenic peripheral lymphoid tissues and may be an evolutionarily primitive system in which immature B cells switch to IgA production at peripheral sites.
| Type de document: | Article |
|---|---|
| Mots-clés libres: | - |
| Centre: | Centre INRS-Institut Armand Frappier |
| Date de dépôt: | 11 avr. 2025 21:28 |
| Dernière modification: | 11 avr. 2025 21:28 |
| URI: | https://espace.inrs.ca/id/eprint/14933 |
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