Lavastre, Valérie; Chiasson, Sonia; Cavalli, Hélène et Girard, Denis 
ORCID: https://orcid.org/0000-0002-3342-5027
(2005).
Viscum album agglutinin-I (VAA-I) induces apoptosis and degradation of cytoskeletal proteins in human leukemia PLB-985 and X-CGD cells via caspases: Lamin B-1 is a novel target of VAA-I
Leukemia Research
, vol. 29
, nº 12.
pp. 1443-1453.
DOI: 10.1016/j.leukres.2005.05.014.
Résumé
Viscum album agglutinin-I (VAA-I) is a potent inducer of cell apoptosis and possesses anti-tumoral activity. Using PLB-985 and chronic granulomatous disease (X-CGD) cells, which lack expression of gp91(phox), VAA-I was found to induce apoptosis in both cell lines as assessed by cytology, DNA laddering and degradation of the cytoskeletal protein gelsolin. Both cell lines expressed caspase-3 and -8 and VAA-I activated these caspases. We demonstrated that lamin B-1 is a novel target to VAA-I and its degradation was reversed by a pan-caspase inhibitor and by a caspase-6, but not a caspase-8, inhibitor.
| Type de document: | Article |
|---|---|
| Mots-clés libres: | Leukemia cells; Apoptosis; Caspases; Plant lectin; Microfilaments; Intermediate filaments; Lamin B1; Gelsolin; Vimentin |
| Centre: | Centre INRS-Institut Armand Frappier |
| Date de dépôt: | 11 nov. 2024 20:12 |
| Dernière modification: | 11 nov. 2024 20:12 |
| URI: | https://espace.inrs.ca/id/eprint/14867 |
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