Jobin, Nathalie; Garrel, Dominique R.; Champoux, Julie et Bernier, Jacques 
ORCID: https://orcid.org/0000-0002-0594-5922
(2000).
Improved immune functions with administration of a low-fat diet in a burn animal model
Cellular Immunology
, vol. 206
, nº 2.
pp. 71-84.
DOI: 10.1006/cimm.2000.1728.
Résumé
The purpose of this study was to characterize the impact of a low-fat (LF; 1% fat) diet, a high-fat (HF; 25% fat) diet, and a standard (SD; 5% fat) diet on immune and oxidative parameters in a 20% body surface area burn animal model fed nd libitum for 10 days postinjury. Although the mechanisms are poorly understood, the amount of dietary lipid in nutritional support has been shown to have immunomodulatory effects after burn injury. Burned mice fed the LF diet showed a normal response in activated splenocyte proliferation compared to burned animals that received the SD or HF diet. Animals fed the SD and HF diets presented increased production of nitric oxide and prostaglandin E-2 response after burn injury, which is associated with inhibited splenocyte proliferation. The total thiol concentration in spleen cells from burned animals kept on the HF diet was significantly higher than that in unburned animals, while no increase in these oxidative parameters was observed in LF-fed burned animals. Moreover, the LF diet significantly reduced hepatic lipid peroxidation, as measured by malonaldehyde concentration, compared to the other two diets. These results suggest that the administration of a LF diet in mice after a burn injury prevents inhibition of in vitro splenocyte proliferation and reduces the intensity of oxidative stress.
| Type de document: | Article |
|---|---|
| Mots-clés libres: | burns; dietary lipids; immunosuppression; oxidative stress |
| Centre: | Centre INRS-Institut Armand Frappier |
| Date de dépôt: | 11 avr. 2025 12:53 |
| Dernière modification: | 11 avr. 2025 12:53 |
| URI: | https://espace.inrs.ca/id/eprint/14775 |
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