Grison, Claude; Comoy, Corinne; Chatenet, David 
ORCID: https://orcid.org/0000-0002-7270-4328 et Coutrot, Philippe
(2002).
Synthesis of P-chiral enephosphonic acid derivatives
Journal of Organometallic Chemistry
, vol. 662
, nº 1–2.
pp. 83-97.
DOI: 10.1016/S0022-328X(02)01889-2.
Résumé
An efficient and convenient synthesis of chiral enephosphonic acid derivatives (enephosphonates, enephosphonamides, enephosphinates) was reported by a two-step procedure involving alkylidenediphosphorylation of nucleophiles followed by a Horner–Emmons olefination. Depending on the selected strategy, the synthesis could be executed according to a one-pot or a two-step reaction sequence. Regioselectivity of Horner–Emmons reaction and 31P-NMR study of diphosphorylated anions were described.
Synthesis of P-chiral enephosphonic acid derivatives. A synthesis of chiral enephosphonic acid derivatives (enephosphonates, enephosphonamides, enephosphinates) was reported by a two-step procedure involving alkylidene diphosphorylation of nucleophiles followed by a Horner–Emmons olefination. Depending on the selected strategy, the synthesis could be executed according to a one-pot or a two-step reaction sequence. Regioselectivity of Horner–Emmons reaction and 31P-NMR study of diphosphorylated anions were described.
| Type de document: | Article |
|---|---|
| Mots-clés libres: | Alkylidenediphosphorylation; Horner reaction; Diphosphorylated carbanions; 31P-NMR study; Chiral enephosphorylated derivatives |
| Centre: | Centre INRS-Institut Armand Frappier |
| Date de dépôt: | 03 mars 2025 21:02 |
| Dernière modification: | 03 mars 2025 21:02 |
| URI: | https://espace.inrs.ca/id/eprint/14725 |
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