Graziano, Monica; St-Pierre, Yves 
ORCID: https://orcid.org/0000-0002-1948-2041 et Potworowski, Edouard F.
(2001).
UEA-I-binding to thymic medullary epithelial cells selectively reduces numbers of cortical TCR alpha beta(+) thymocytes in FTOCs
Immunology Letters
, vol. 77
, nº 3.
pp. 143-150.
DOI: 10.1016/s0165-2478(01)00218-8.
Résumé
Thymic medullary epithelial cells (TMECs) constitute a major stromal cell type, the function of which is incompletely understood. Some TMECs express L-fucose-glycosylated proteins on their plasma membrane; these have been shown to specifically bind the lectin UEA-I. We exploited this observation to investigate the consequences of in situ blockage of TMECs in FTOCs by UEA-I. In UEA-I-treated FTOCs, we noted a decreased cellularity among TCR alpha beta (+) but not TCR gamma delta (+) cells. In fact, CD3(-) and CD3(1 omicron) cortical cells were markedly depleted, while CD3(h1) cells were unaffected. Since the affected cell subsets are in a different compartment from that where UEA-I binding occurs, it is likely that the effect is mediated through a soluble factor. Two possible mechanisms are proposed: a reduced activation of either TMECs or of medullary thymocytes which normally bind to them, results in lowered production of soluble factors responsible for cortical thymocyte proliferation. Alternately, the binding of UEA-I to TMECs could activate the latter to produce signals inhibitory to cortical thymocytes.
| Type de document: | Article |
|---|---|
| Mots-clés libres: | Thymus; Stromal cells; T lymphocytes; Cell-to-cell interactions; UEA-I |
| Centre: | Centre INRS-Institut Armand Frappier |
| Date de dépôt: | 07 mars 2025 21:21 |
| Dernière modification: | 07 mars 2025 21:21 |
| URI: | https://espace.inrs.ca/id/eprint/14719 |
Gestion Actions (Identification requise)
 |
Modifier la notice |