Garg, Ravendra; Lodge, Robert; Descoteaux, Albert 
ORCID: https://orcid.org/0000-0002-0633-5309 et Tremblay, Michel J
(2008).
Leishmania infantum promastigotes reduce entry of HIV-1 into macrophages through a lipophosphoglycan-mediated disruption of lipid rafts
Journal of Infectious Diseases
, vol. 197
, nº 12.
pp. 1701-1708.
DOI: 10.1086/588146.
Résumé
Visceral leishmaniasis is now recognized as an opportunistic disease in patients infected with human immunodeficiency virus type 1 (HIV-1). We report here that Leishmania infantum promastigotes enhance HIV-1 replication in monocyte-derived macrophages (MDMs) at late time points in the virus growth curve but also that, surprisingly, a reduction in HIV-1 production is seen during the initial days after infection. This early effect is caused by a Leishmania-mediated inhibition of virus entry into MDMs through the action of lipophosphoglycan (LPG), the major promastigote surface glycolipid. The impact of LPG in the observed phenomenon was confirmed using LPG-defective lpg1-/- knockout mutant promastigotes. Our results suggest that the LPG-mediated effect results from the disruption of lipid rafts. Altogether, these findings suggest that the presence of Leishmania within the same cellular microenvironment leads to 2 opposite, time-dependent effects on HIV-1 replication. Leishmania and HIV-1 can thus establish complex interactions in their common natural host cells.
| Type de document: | Article |
|---|---|
| Mots-clés libres: | - |
| Centre: | Centre INRS-Institut Armand Frappier |
| Date de dépôt: | 22 juill. 2024 19:46 |
| Dernière modification: | 22 juill. 2024 19:46 |
| URI: | https://espace.inrs.ca/id/eprint/14685 |
Gestion Actions (Identification requise)
 |
Modifier la notice |