Escarné, Regina; Gagné, François; Dautremepuits, Claire; Cyr, Daniel G. 
ORCID: https://orcid.org/0000-0002-6566-783X; Finnson, Kenneth; Marcogliese, David J.; Bernier, Jacques ORCID: https://orcid.org/0000-0002-0594-5922; Cejka, Patrick et Fournier, Michel
(2008).
Effects of municipal sewage effluent on non-specific immune and thyroid functions of rainbow trout (Oncorhynchus mykiss)
Trends in Comparative Biochemistry & Physiology
, vol. 13
.
pp. 27-39.
Résumé
Municipal sewage effluents contain complex mixts. of chem. and biol. substances known to disrupt immunol. functions in fish. Juvenile rainbow trout (Oncorhynchus mykiss) were exposed to concns. of a primary-treated effluent for 45 d at 15°C in semi-static conditions. After the exposure period, the immune status - phagocytic activity, proliferation of B- and T-lymphocytes, and the ability to remove the pathogenic bacterium Aeromonas salmonicida were detd. In parallel, hepatic T4 5'-deiodinase activity was detd. The results showed that the phagocytic response was bimodal; active phagocytosis was inhibited at the lowest concn. (0.003% vol./vol.) but induced at higher concns. (≥0.03% up to 3% vol./vol.). The effluent inhibited proliferation of both T- and B-lymphocytes, but the inhibition was more severe for B-lymphocytes, suggesting that humoral immunity was more affected than cell-mediated immunity. The proportion of infected trout dropped in trout exposed to effluent compared to trout in aquarium water, suggesting that bacteria found in the effluent might have immunized fish against the pathogenic bacteria challenge. High Km hepatic T4 5'-deiodinase activity was increased at one effluent concn. and was neg. correlated with active phagocytosis and proliferation of T-lymphocytes but was pos. correlated with proliferation of B-lymphocytes. Hierarchical tree anal. of the data revealed that phagocytic activity was closely assocd. with proliferation of T-lymphocytes while B-lymphocyte activity was more closely correlated with high Km T4 5'-deiodinase activity and the likelihood of developing an A. salmonicida infection. Municipal effluents have the potential to affect the thyroid and immune system of fish exposed for long periods at relatively low concns. (≤3% vol./vol.). Investigation of the immune status of feral fish populations and of the possible interplay between the immune system and thyroid status is warranted. [on SciFinder(R)]
| Type de document: | Article |
|---|---|
| Mots-clés libres: | - |
| Centre: | Centre INRS-Institut Armand Frappier |
| Date de dépôt: | 21 juill. 2024 19:17 |
| Dernière modification: | 21 juill. 2024 19:17 |
| URI: | https://espace.inrs.ca/id/eprint/14650 |
Gestion Actions (Identification requise)
 |
Modifier la notice |