Dupéré-Minier, Geneviève; Desharnais, Philippe et Bernier, Jacques 
ORCID: https://orcid.org/0000-0002-0594-5922
(2010).
Involvement of tyrosine phosphatase CD45 in apoptosis
Apoptosis
, vol. 15
, nº 1.
pp. 1-13.
DOI: 10.1007/s10495-009-0413-z.
Résumé
CD45 is a transmembrane molecule with phosphatase activity expressed in all nucleated haematopoietic cells and plays a major role in immune cells. It is a protein tyrosine phosphatase that is essential for antigen-receptor-mediated signal transduction by regulating Src family members that initiate TCR signaling. CD45 is being attributed a new emerging role as an apoptosis regulator. Cross-linking of the extracellular portion of the CD45 by monoclonal antibodies and by galectin-1, can induce apoptosis in T and B cells. Interestingly, this phosphatase has also been involved in nuclear apoptosis induced by mitochondrial perturbing agents. Furthermore, it is involved in apoptosis induced by HIV-1. CD45 defect is implicated in various diseases such as severe-combined immunodeficiency disease (SCID), acquired immunodeficiency syndrome (AIDS), lymphoma and multiple myelomas. The understanding of the mechanisms by which CD45 regulates apoptosis would be very useful in disease treatment.
| Type de document: | Article |
|---|---|
| Mots-clés libres: | - |
| Centre: | Centre INRS-Institut Armand Frappier |
| Date de dépôt: | 30 juin 2024 17:28 |
| Dernière modification: | 30 juin 2024 17:28 |
| URI: | https://espace.inrs.ca/id/eprint/14639 |
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