Delbès, Géraldine 
ORCID: https://orcid.org/0000-0002-9169-1075; Vaisheva, Farida; Luu, Trang; Marcon, Ludovic; Hales, Barbara F. et Robaire, Bernard
(2010).
Reversibility of the effects of the chemotherapeutic regimen for non-Hodgkin lymphoma, cyclophosphamide, doxorubicin, vincristine, and prednisone, on the male rat reproductive system and progeny outcome
Reproductive Toxicology
, vol. 29
, nº 3.
pp. 332-8.
DOI: 10.1016/j.reprotox.2010.01.007.
Résumé
The chemotherapeutic agents used to treat non-Hodgkin lymphoma, cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP), have adverse effects on male reproductive function and progeny outcome. To determine the reversibility of these effects, male rats received a CHOP treatment mimicking human exposure. CHOP reduced testicular and epididymal weights; these remained decreased after 9 weeks recovery. This treatment also decreased testicular sperm number and increased spermatozoal DNA damage. Although sperm production returned to control values after 9 weeks recovery, DNA damage persisted. Decreased litter size, and increased pre- and post-implantation losses were observed among litters sired by CHOP-exposed males. Litter size and pre-implantation loss returned to control within 3 weeks post-treatment and post-implantation loss by 6 weeks. Thus, effects of CHOP on progeny outcome were reversed 9 weeks post-treatment, although germ cell DNA breaks remained elevated. These data suggest that the ability to sire viable progeny may not be a sensitive measure of spermatozoal quality in rats.
| Type de document: | Article |
|---|---|
| Mots-clés libres: | Spermatozoa DNA damage Male reproductive toxicity |
| Centre: | Centre INRS-Institut Armand Frappier |
| Date de dépôt: | 29 juin 2024 21:36 |
| Dernière modification: | 29 juin 2024 21:36 |
| URI: | https://espace.inrs.ca/id/eprint/14569 |
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