Cellier, Mathieu 
ORCID: https://orcid.org/0000-0002-6084-434X; Bergevin, Isabelle; Boyer, Élise et Richer, Étienne
(2001).
Polyphyletic origins of bacterial Nramp transporters
Trends in Genetics
, vol. 17
, nº 7.
pp. 365-370.
DOI: 10.1016/s0168-9525(01)02364-2.
Résumé
The redox-active metals iron and manganese are required for energy metabolism, protection against oxidative stress and defense against infections. In eukaryotes, both divalent metals are transported by Nramp transporters. The sequence of these transporters was remarkably conserved during evolution. Several bacterial Nramp homologs (MntH) are also proton-dependent manganese transporters. Here, we present phylogenetic evidence for the polyphyletic origins of three groups of MntH proteins and for possible Nramp horizontal gene transfer with eukaryotes. We propose that the evolution of the MntH/Nramp family is related to adaptation to oxidative environments, including those arising during infection of animals and plants.
| Type de document: | Article |
|---|---|
| Mots-clés libres: | metal ion; membrane transport; horizontal gene transfer; bacterial infection host defence |
| Centre: | Centre INRS-Institut Armand Frappier |
| Date de dépôt: | 03 mars 2025 15:52 |
| Dernière modification: | 03 mars 2025 15:52 |
| URI: | https://espace.inrs.ca/id/eprint/14479 |
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