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Nramp1 phagocyte intracellular metal withdrawal defense

Cellier, Mathieu ORCID logoORCID: https://orcid.org/0000-0002-6084-434X; Courville, Pascal et Campion, Carole (2007). Nramp1 phagocyte intracellular metal withdrawal defense Microbes and Infection , vol. 9 , nº 14-15. pp. 1662-1670. DOI: 10.1016/j.micinf.2007.09.006.

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Résumé


Natural resistance-associated macrophage proteins (Nramp) are multispecific symporters facilitating proton-dependent import of divalent metals. Nramp1 restricts microbial access to essential micro-nutrients such as iron and manganese within professional phagosomes. Increased understanding of Nramp1 roles in human phagocytes will be useful for future therapeutic approaches against selected infectious and immune diseases.

Type de document: Article
Mots-clés libres: Divalent cations; Transport proteins; Phagosomes
Centre: Centre INRS-Institut Armand Frappier
Date de dépôt: 22 oct. 2024 19:46
Dernière modification: 22 oct. 2024 19:46
URI: https://espace.inrs.ca/id/eprint/14478

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