Beffert, Uwe; Danik, Marc; Krzywkowski, Pascale; Ramassamy, Charles 
ORCID: https://orcid.org/0000-0002-3252-5878; Berrada, Fouad et Poirier, Judes
(1998).
The neurobiology of apolipoproteins and their receptors in the CNS and Alzheimer's disease
Brain Research. Brain Research Reviews
, vol. 27
, nº 2.
pp. 119-142.
DOI: 10.1016/s0165-0173(98)00008-3.
Résumé
The importance of apolipoproteins in the central nervous system became increasingly clear with the association in 1993 of the epsilon4 allele of apolipoprotein E with familial and sporadic late-onset Alzheimer's disease. Apolipoprotein E is a ligand for several receptors, most of which are found to some extent in the brain. This review summarizes the various apolipoproteins and lipoprotein receptors found in the brain. A growing body of evidence now implicates irregular lipoprotein metabolism in several neurodegenerative disorders. We then focus on research linking apolipoprotein E and Alzheimer's disease, from clinical studies to biochemical models, which may explain some of the complex neurobiology of this disorder.
| Type de document: | Article |
|---|---|
| Mots-clés libres: | Apolipoprotein E Alzheimer's disease Brain Low density lipoprotein receptor Low density lipoprotein receptor related protein Apolipoprotein J Apolipoprotein D Very low density lipoprotein receptor Apolipoprotein E receptor 2 Neuronal plasticity Cholinergic dysfunction |
| Centre: | Centre INRS-Institut Armand Frappier |
| Date de dépôt: | 07 juill. 2025 18:21 |
| Dernière modification: | 07 juill. 2025 18:21 |
| URI: | https://espace.inrs.ca/id/eprint/14395 |
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