Vilela, Larissa D; Désy, Marie et Parent, Marie-Élise 
ORCID: https://orcid.org/0000-0002-4196-3773
(2011).
Lifetime stress at work and risk of prostate cancer
In: Abstracts of the 3rd North American Congress of Epidemiology, June 21-24, 2011 Montreal, Canada, June, 21-24, 2011, Montréal, Québec.
Résumé
Psychosocial factors may play a role in cancer aetiology. Potential mechanisms proposed include an alteration of the immune function and/or of
hormone levels. Several studies have suggested a link between stress and
breast cancer risk. Hardly any evidence exists for other cancer types. Prostate cancer is thought to be influenced, at least in part, by environmental
circumstances modulating hormone levels. We report here on the association between lifelong stress at work and prostate cancer risk in the context
of a case-control study involving 973 incident, pathology confirmed prostate cancer cases and 1,087 population controls in Montreal, Canada. As
part of in-person interviews, subjects were asked to provide a detailed description of each job held over their lifetime, including specific tasks, and
were asked to indicate whether these jobs made them feel tense, anxious or
stressed. Regression analysis was used to estimate odds ratio (OR) and 95%
confidence intervals (CI) associated with stress at work, while adjusting for
age, ethnicity, first-degree family history of prostate cancer and education.
Compared to men reporting no work-related stress, the OR among those
who did increased with longer cumulative durations of work-related stress
(p for trend = 0.023). The ORs for prostate cancer according to the duration of work-related stress were: OR(1-10 years) = 1.12, 95%CI 0.81-1.54;
OR(11-20 years) = 1.17, 95%CI 0.87-1.58; OR(21-30 years) = 1.32,
95%CI 1.00-1.74; OR(more than 30 years) = 1.29, 95%CI 1.02-1.64.
Results remained unaltered when income, smoking, alcohol intake and
body mass index were accounted for. Our findings of an association between work-related stress and prostate cancer are largely novel and require
replication in other studies.
| Type de document: | Document issu d'une conférence ou d'un atelier |
|---|---|
| Informations complémentaires: | Affiche scientifique 645-S American Journal of Epidemiology 173(11: Suppl. 1):S161 |
| Mots-clés libres: | - |
| Centre: | Centre INRS-Institut Armand Frappier |
| Date de dépôt: | 30 mars 2024 17:48 |
| Dernière modification: | 30 mars 2024 17:48 |
| URI: | https://espace.inrs.ca/id/eprint/14323 |
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