Dépôt numérique

Is occupational physical activity associated with cancer risk among men?

Parent, Marie-Élise ORCID logoORCID: https://orcid.org/0000-0002-4196-3773; Siemiatycki, Jack; Latreille, Benoît et Désy, Marie (2005). Is occupational physical activity associated with cancer risk among men? In: Joint Meeting of the Society for Epidemiologic Research/Canadian Society for Epidemiology and Biostatistics, June 27-30, 2005, Toronto, Canada.

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High physical activity levels might exert a protective effect against certain cancers through a modulation of hormone levels, growth factors or immune function. However, the epidemiological evidence for such an association remains largely unclear. We present here results from an analysis of a population-based case-control study undertaken in Montreal in the 1980s to investigate the association between occupational and lifestyle factors, and cancer at several sites. Interviews were carried out with incident male cases of cancer of the lung (n=857), colon (n=497), bladder (n=484), prostate (n=449), rectum (n=257), stomach (n=251), kidney (n=177), melanoma (n=103), esophagus (n=99), pancreas (n=116), liver (n=48), non-Hodgkin's lymphoma (n=215), Hodgkin's lymphoma (n=54), and 533 population controls. Each job reported by each subject was coded for physical activity levels using metabolic equivalents (METs), calculated based on the metabolic rate for specific tasks within the job divided by the resting metabolic rate. Logistic regression analyses were carried out to assess the odds ratio (OR) and 95% confidence interval (95%CI) for each cancer type associated with a work history characterized by high physical demand, adjusting for sitespecific potential confounders. As compared to men having held sedentary jobs (METs of 1.5 or less), the OR for men who had worked in physically demanding jobs (METs of 4 or more for at least 75% of their work years) was 0.52 (95%CI=0.29-0.92) for colon, 0.60 (95%CI=0.36--l.02) for prostate, 0.51 (95%CI=0.27--{).96) for bladder cancers, and 0.15 (95%CI=0.03- 0. 77) for melanoma. Trends of lowered risks were also noted for cancers of the lung (OR=0.82), stomach (OR=0.65), pancreas (OR=0.31), Hodgkin's (OR=0.58) and non-Hodgkin's (OR=0.61) lymphomas. These findings are in line with a protective effect of prolonged, high occupational physical activity levels across a wide range of cancer types.

Type de document: Document issu d'une conférence ou d'un atelier
Informations complémentaires: American Journal of Epidemiology 161 (Suppl 1): S93
Mots-clés libres: -
Centre: Centre INRS-Institut Armand Frappier
Date de dépôt: 12 mars 2024 15:47
Dernière modification: 12 mars 2024 15:47
URI: https://espace.inrs.ca/id/eprint/14311

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