Dépôt numérique

Role of complement in the early stages of viral infections

Langlois, Marie-Pierre; Tarrab, Esther et Lamarre, Alain ORCID logoORCID: https://orcid.org/0000-0002-7913-871X (2012). Role of complement in the early stages of viral infections In: XXIV. International Complement Workshop, October 10–15, 2012, Chania, Crete, Greece.

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Each year, millions of people are infected by viruses. Some infections are rapidly eliminated while others persist in the host. For an effective clearance of virus infections, interactions between the innate and adaptive arms of the immune system are important. Natural antibodies, which are found in the blood of naive individuals, are important effectors of the innate immune system. The major role attributed to natural antibodies is to recognize pathogens in the early stages of infection. Work from our laboratory recently showed that a more diversified natural antibody repertoire allows for a more effective antiviral cellular immune response. However, the role of complement in this process is unknown. Following infection with VSV, titers found in the spleen were lower in complement depleted B6 mice compared to control animals. In LCMV infected B6 mice, no such difference in viral dissemination 24 h after infection were observed in complement depleted mice which lead to no significant differences in LCMV-specific T cell responses 8 days post infection. To test the influence of complement in viral dissemination and T cell priming independently of antibodies, B cell deficient JHT mice were depleted of complement and viral dissemination and T cell responses determined. In this case, titers in the spleen following VSV and LCMV infection were significantly lower in complement depleted JHT mice. Surprisingly, decomplemented JHT mice showed slightly increased antiviral T cell responses compared to untreated animals indicating that complement might interfere with antigen presentation in the absence of antibodies. Therefore, in the first hours after infection, the presence of complement appears to promote virus recruitment in the spleen in antibody deficient animals, however, this does not translate into greater priming at the peak of the immune response. Mechanisms underlying this phenomenon could help our understanding of the clearance of HCV infection in humans.

Type de document: Document issu d'une conférence ou d'un atelier
Informations complémentaires: Présentation orale 203 Immunobiology 217(11):1200-1201
Mots-clés libres: -
Centre: Centre INRS-Institut Armand Frappier
Date de dépôt: 28 janv. 2024 15:01
Dernière modification: 28 janv. 2024 15:01
URI: https://espace.inrs.ca/id/eprint/14130

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