Langlois, Marie-Pierre; Tarrab, Esther et Lamarre, Alain 
ORCID: https://orcid.org/0000-0002-7913-871X
(2012).
Role of complement in the early stages of viral infections
In: XXIV. International Complement Workshop, October 10–15, 2012, Chania, Crete, Greece.
Résumé
Each year, millions of people are infected by viruses. Some infections are rapidly eliminated while others persist in the host. For
an effective clearance of virus infections, interactions between the
innate and adaptive arms of the immune system are important. Natural antibodies, which are found in the blood of naive individuals,
are important effectors of the innate immune system. The major
role attributed to natural antibodies is to recognize pathogens in
the early stages of infection. Work from our laboratory recently
showed that a more diversified natural antibody repertoire allows
for a more effective antiviral cellular immune response. However,
the role of complement in this process is unknown. Following infection with VSV, titers found in the spleen were lower in complement
depleted B6 mice compared to control animals. In LCMV infected
B6 mice, no such difference in viral dissemination 24 h after infection were observed in complement depleted mice which lead to
no significant differences in LCMV-specific T cell responses 8 days
post infection. To test the influence of complement in viral dissemination and T cell priming independently of antibodies, B cell deficient JHT mice were depleted of complement and viral dissemination and T cell responses determined. In this case, titers in the
spleen following VSV and LCMV infection were significantly lower
in complement depleted JHT mice. Surprisingly, decomplemented
JHT mice showed slightly increased antiviral T cell responses compared to untreated animals indicating that complement might
interfere with antigen presentation in the absence of antibodies.
Therefore, in the first hours after infection, the presence of complement appears to promote virus recruitment in the spleen in
antibody deficient animals, however, this does not translate into
greater priming at the peak of the immune response. Mechanisms
underlying this phenomenon could help our understanding of the
clearance of HCV infection in humans.
| Type de document: | Document issu d'une conférence ou d'un atelier |
|---|---|
| Informations complémentaires: | Présentation orale 203 Immunobiology 217(11):1200-1201 |
| Mots-clés libres: | - |
| Centre: | Centre INRS-Institut Armand Frappier |
| Date de dépôt: | 28 janv. 2024 15:01 |
| Dernière modification: | 28 janv. 2024 15:01 |
| URI: | https://espace.inrs.ca/id/eprint/14130 |
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