Vu, Khanh Dang; Carlettini, Helene; Bouvet, Janie; Cote, Jacinthe; Doyon, Gilles; Sylvain, Jean-Francois et Lacroix, Monique 
ORCID: https://orcid.org/0000-0002-2042-4033
(2012).
Effect of different cranberry extracts and juices during cranberry juice processing on the antiproliferative activity against two colon cancer cell lines
Food Chemistry
, vol. 132
, nº 2.
pp. 959-967.
DOI: 10.1016/j.foodchem.2011.11.078.
Résumé
The effect of cranberry exts. and juices during cranberry juice processing on the antiproliferative properties against colon cancer cells was investigated. Two colon cancer cell lines HT-29 and LS-513 were treated with different concns. of cranberry phenolic exts. from fruits, puree, depectinised puree and pomace and different concn. of three juices (raw, filtered and concd. juices). The phenolic exts. consisted of water-sol. phenolic compds., apolar phenolic compds. and anthocyanins. These phenolic exts. and juices were tested against two cell lines at pH 2.5 (natural juice pH) and at pH 7.0 (physiol. pH). All cranberry exts. and juices could inhibit the growth of both cell lines with the IC50 values (the concn. of phenolic content required to inhibit 50% the growth of cancer cells) varied from 3.8 to 179.2 μg gallic acid equiv./mL. It was found that three types of exts. from fruit at pH 7.0 were the most effective at inhibiting the growth of HT-29 cell line. Exts. contg. anthocyanins from fruit and from pomace were the most and the least efficient, resp., in inhibiting the growth of both cancer cell lines. Further, three juices at natural pH (pH 2.5) were more effective at inhibiting the growth of two cell lines as compared to juices at pH 7.0. Concd. juice at both pH values was the most effective at growth inhibition of two cancer cell lines compared to two other juices. [on SciFinder(R)]
| Type de document: | Article |
|---|---|
| Mots-clés libres: | Cranberry fruit; Juice processing; Phenolic extracts; Antiproliferative activity Colon cancer cells |
| Centre: | Centre INRS-Institut Armand Frappier |
| Date de dépôt: | 09 mars 2024 21:45 |
| Dernière modification: | 09 mars 2024 21:45 |
| URI: | https://espace.inrs.ca/id/eprint/14105 |
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