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CD8(+) T cells in leishmania infections: friends or foes?


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Stäger, Simona ORCID logoORCID: https://orcid.org/0000-0001-5508-9565 et Rafati, Sima (2012). CD8(+) T cells in leishmania infections: friends or foes? Frontiers in immunology , vol. 3 , nº 5. pp. 1-8. DOI: 10.3389/fimmu.2012.00005.

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Host protection against several intracellular pathogens requires the induction of CD8(+) T cell responses. CD8(+) T cells are potent effector cells that can produce high amounts of pro-inflammatory cytokines and kill infected target cells efficiently. However, a protective role for CD8(+) T cells during Leishmania infections is still controversial and largely depends on the infection model. In this review, we discuss the role of CD8(+) T cells during various types of Leishmania infections, following vaccination, and as potential immunotherapeutic targets.

Type de document: Article
Mots-clés libres: CD8 T cells; Leishmania; immunology.
Centre: Centre INRS-Institut Armand Frappier
Date de dépôt: 08 mars 2024 20:16
Dernière modification: 08 mars 2024 20:16
URI: https://espace.inrs.ca/id/eprint/14093

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