Herdy, Barbara; Jaramillo, Maritza 
ORCID: https://orcid.org/0000-0002-1910-5684; Svitkin, Yuri V.; Rosenfeld, Amy B.; Kobayashi, Mariko; Walsh, Derek; Alain, Tommy; Sean, Polen; Robichaud, Nathaniel; Topisirovic, Ivan; Furic, Luc; Dowling, Ryan J O.; Sylvestre, Annie; Rong, Liwei; Colina, Rodney; Costa-Mattioli, Mauro; Fritz, Jorg H; Olivier, Martin; Brown, Earl; Mohr, Ian et Sonenberg, Nahum
(2012).
Translational control of the activation of transcription factor NF-kappaB and production of type I interferon by phosphorylation of the translation factor eIF4E
Nature Immunology
, vol. 13
, nº 6.
pp. 543-50.
DOI: 10.1038/ni.2291.
Résumé
Type I interferon is an integral component of the antiviral response, and its production is tightly controlled at the levels of transcription and translation. The eukaryotic translation-initiation factor eIF4E is a rate-limiting factor whose activity is regulated by phosphorylation of Ser209. Here we found that mice and fibroblasts in which eIF4E cannot be phosphorylated were less susceptible to virus infection. More production of type I interferon, resulting from less translation of Nfkbia mRNA (which encodes the inhibitor IkappaBalpha), largely explained this phenotype. The lower abundance of IkappaBalpha resulted in enhanced activity of the transcription factor NF-kappaB, which promoted the production of interferon-beta (IFN-beta). Thus, regulated phosphorylation of eIF4E has a key role in antiviral host defense by selectively controlling the translation of an mRNA that encodes a critical suppressor of the innate antiviral response.
| Type de document: | Article |
|---|---|
| Mots-clés libres: | - |
| Centre: | Centre INRS-Institut Armand Frappier |
| Date de dépôt: | 04 mars 2024 16:36 |
| Dernière modification: | 04 mars 2024 16:36 |
| URI: | https://espace.inrs.ca/id/eprint/14036 |
Gestion Actions (Identification requise)
 |
Modifier la notice |