Genomic analysis of sewage from 101 countries reveals global landscape of antimicrobial resistance.

Munk, Patrick ORCID: https://orcid.org/0000-0001-8813-4019; Brinch, Christian ORCID: https://orcid.org/0000-0002-5074-7183; Møller, Frederik Duus; Petersen, Thomas N.; Hendriksen, Rene S.; Seyfarth, Anne Mette; Kjeldgaard, Jette S.; Svendsen, Christina Aaby; van Bunnik, Bram ORCID: https://orcid.org/0000-0003-2177-7073; Berglund, Fanny ORCID: https://orcid.org/0000-0002-8528-8095; Bego, Artan; Power, Pablo; Rees, Catherine; Lambrinidis, Dionisia; Neilson, Elizabeth Heather Jakobsen; Gibb, Karen; Coventry, Kris; Collignon, Peter; Cassar, Susan; Allerberger, Franz; Begum, Anowara; Hossain, Zenat Zebin; Worrell, Carlon; Vandenberg, Olivier; Pieters, Ilse; Victorien, Dougnon Tamègnon; Gutierrez, Angela Daniela Salazar; Soria, Freddy; Grujić, Vesna Rudić; Mazalica, Nataša; Rahube, Teddie O.; Tagliati, Carlos Alberto; Rodrigues, Dalia; Oliveira, Guilherme; de Souza, Larissa Camila Ribeiro; Ivanov, Ivan; Juste, Bonkoungou Isidore; Oumar, Traoré; Sopheak, Thet; Vuthy, Yith; Ngandjio, Antoinette; Nzouankeu, Ariane; Olivier, Ziem A. Abah Jacques; Yost, Christopher K.; Kumar, Pratik; Brar, Satinder Kaur; Tabo, Djim-Adjim; Adell, Aiko D.; Paredes-Osses, Esteban; Martinez, Maria Cristina; Cuadros-Orellana, Sara; Ke, Changwen; Zheng, Huanying; Baisheng, Li; Lau, Lok Ting; Chung, Teresa; Jiao, Xiaoyang; Yu, Yongjie; JiaYong, Zhao; Morales, Johan F. Bernal; Valencia, Maria Fernanda; Donado-Godoy, Pilar; Coulibaly, Kalpy Julien; Hrenovic, Jasna; Jergović, Matijana; Karpíšková, Renáta; Deogratias, Zozo Nyarukweba; Elsborg, Bodil; Hansen, Lisbeth Truelstrup; Jensen, Pernille Erland; Abouelnaga, Mohamed; Salem, Mohamed Fathy; Koolmeister, Marliin; Legesse, Mengistu; Eguale, Tadesse; Heikinheimo, Annamari; Le Guyader, Soizick; Schaeffer, Julien; Villacis, Jose Eduardo; Sanneh, Bakary; Malania, Lile; Nitsche, Andreas; Brinkmann, Annika; Schubert, Sara; Hesse, Sina; Berendonk, Thomas U.; Saba, Courage Kosi Setsoafia; Mohammed, Jibril; Feglo, Patrick Kwame; Banu, Regina Ama; Kotzamanidis, Charalampos; Lytras, Efthymios; Lickes, Sergio A.; Kocsis, Bela; Solymosi, Norbert; Thorsteinsdottir, Thorunn R.; Hatha, Abdulla Mohamed; Ballal, Mamatha; Bangera, Sohan Rodney; Fani, Fereshteh; Alebouyeh, Masoud; Morris, Dearbhaile; O’Connor, Louise; Cormican, Martin; Moran-Gilad, Jacob; Battisti, Antonio; Diaconu, Elena Lavinia; Corno, Gianluca; Di Cesare, Andrea; Alba, Patricia; Hisatsune, Junzo; Yu, Liansheng; Kuroda, Makoto; Sugai, Motoyuki; Kayama, Shizuo; Shakenova, Zeinegul; Kiiyukia, Ciira; Ng’eno, Eric; Raka, Lul; Jamil, Kazi; Fakhraldeen, Saja Adel; Alaati, Tareq; Bērziņš, Aivars; Avsejenko, Jeļena; Kokina, Kristina; Streikisa, Madara; Bartkevics, Vadims; Matar, Ghassan M.; Daoud, Ziad; Pereckienė, Asta; Butrimaite-Ambrozeviciene, Ceslova; Penny, Christian; Bastaraud, Alexandra; Rasolofoarison, Tiavina; Collard, Jean-Marc; Samison, Luc Hervé; Andrianarivelo, Mala Rakoto; Banda, Daniel Lawadi; Amin, Arshana; Rajandas, Heraa; Parimannan, Sivachandran; Spiteri, David; Haber, Malcolm Vella; Santchurn, Sunita J.; Vujacic, Aleksandar; Djurovic, Dijana; Bouchrif, Brahim; Karraouan, Bouchra; Vubil, Delfino Carlos; Pal, Pushkar; Schmitt, Heike; van Passel, Mark; Jeunen, Gert-Jan; Gemmell, Neil; Chambers, Stephen T.; Mendoza, Fania Perez; Huete-Pιrez, Jorge; Vilchez, Samuel; Ahmed, Akeem Olayiwola; Adisa, Ibrahim Raufu; Odetokun, Ismail Ayoade; Fashae, Kayode; Sørgaard, Anne-Marie; Wester, Astrid Louise; Ryrfors, Pia; Holmstad, Rune; Mohsin, Mashkoor; Hasan, Rumina; Shakoor, Sadia; Gustafson, Natalie Weiler; Schill, Claudia Huber; Rojas, Maria Luz Zamudio; Velasquez, Jorge Echevarria; Magtibay, Bonifacio B.; Catangcatang, Kris; Sibulo, Ruby; Yauce, Felipe Campos; Wasyl, Dariusz; Manaia, Celia; Rocha, Jaqueline; Martins, Jose; Álvaro, Pedro; Di Yoong Wen, Doris; Shin, Hanseob; Hur, Hor-Gil; Yoon, Sukhwan; Bosevska, Golubinka; Kochubovski, Mihail; Cojocaru, Radu; Burduniuc, Olga; Hong, Pei-Ying; Perry, Meghan Rose; Gassama, Amy; Radosavljevic, Vladimir; Tay, Moon Y. F.; Zuniga-Montanez, Rogelio; Wuertz, Stefan; Gavačová, Dagmar; Pastuchová, Katarína; Truska, Peter; Trkov, Marija; Keddy, Karen; Esterhuyse, Kerneels; Song, Min Joon; Quintela-Baluja, Marcos; Lopez, Mariano Gomez; Cerdà-Cuéllar, Marta; Perera, R. R. D. P.; Bandara, N. K. B. K. R. G. W.; Premasiri, H. I.; Pathirage, Sujatha; Charlemagne, Kareem; Rutgersson, Carolin; Norrgren, Leif; Örn, Stefan; Boss, Renate; Van der Heijden, Tanja; Hong, Yu-Ping; Kumburu, Happiness Houka; Mdegela, Robinson Hammerthon; Hounmanou, Yaovi Mahuton Gildas; Chonsin, Kaknokrat; Suthienkul, Orasa; Thamlikitkul, Visanu; de Roda Husman, Ana Maria; Bidjada, Bawimodom; Njanpop-Lafourcade, Berthe-Marie; Nikiema-Pessinaba, Somtinda Christelle; Levent, Belkis; Kurekci, Cemil; Ejobi, Francis; Kalule, John Bosco; Thomsen, Jens; Obaidi, Ouidiane; Jassim, Laila Mohamed; Moore, Andrew; Leonard, Anne; Graham, David W.; Bunce, Joshua T.; Zhang, Lihong; Gaze, William H.; Lefor, Brett; Capone, Drew; Sozzi, Emanuele; Brown, Joe; Meschke, John Scott; Sobsey, Mark D.; Davis, Michael; Beck, Nicola Koren; Sukapanpatharam, Pardi; Truong, Phuong; Lilienthal, Ronald; Kang, Sanghoon; Wittum, Thomas E.; Rigamonti, Natalia; Baklayan, Patricia; Van, Chinh Dang; Tran, Doan Minh Nguyen; Do Phuc, Nguyen; Kwenda, Geoffrey; Larsson, D. G. Joakim ORCID: https://orcid.org/0000-0002-5496-0328; Koopmans, Marion ORCID: https://orcid.org/0000-0002-5204-2312; Woolhouse, Mark ORCID: https://orcid.org/0000-0003-3765-8167 et Aarestrup, Frank M. ORCID: https://orcid.org/0000-0002-7116-2723 (2022). Genomic analysis of sewage from 101 countries reveals global landscape of antimicrobial resistance. Nature Communications , vol. 13 , nº 1. p. 7251. DOI: 10.1038/s41467-022-34312-7.

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Résumé

Antimicrobial resistance (AMR) is a major threat to global health. Understanding the emergence, evolution, and transmission of individual antibiotic resistance genes (ARGs) is essential to develop sustainable strategies combatting this threat. Here, we use metagenomic sequencing to analyse ARGs in 757 sewage samples from 243 cities in 101 countries, collected from 2016 to 2019. We find regional patterns in resistomes, and these differ between subsets corresponding to drug classes and are partly driven by taxonomic variation. The genetic environments of 49 common ARGs are highly diverse, with most common ARGs carried by multiple distinct genomic contexts globally and sometimes on plasmids. Analysis of flanking sequence revealed ARG-specific patterns of dispersal limitation and global transmission. Our data furthermore suggest certain geographies are more prone to transmission events and should receive additional attention.

Type de document:	Article
Mots-clés libres:	antimicrobial resistance; metagenomics; microbial ecology; policy and public health in microbiology
Centre:	Centre Eau Terre Environnement
Date de dépôt:	02 nov. 2023 12:38
Dernière modification:	02 nov. 2023 12:38
URI:	https://espace.inrs.ca/id/eprint/13681

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