Tiyuri, Amir; Baghermanesh, Shayeste Sadat; Davatgaran-Taghipour, Yasamin; Eslami, Seyed Sadegh; Shaygan, Nasibeh; Parsaie, Houman; Barati, Mahmood et Jafari, Davod (2023). Diagnostic accuracy of serum derived exosomes for hepatocellular carcinoma: a systematic review and meta-analysis Expert review of molecular diagnostics , vol. 23 , nº 11. pp. 971-983. DOI: 10.1080/14737159.2023.2260306.
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INTRODUCTION: Early and non-invasive detection of hepatocellular carcinoma (HCC), which is usually asymptomatic, can improve overall survival outcomes. The objective of this systematic review and meta-analysis was to evaluate the diagnostic accuracy of serum-derived exosomes for diagnosing HCC. METHODS: PubMed, Web of Science, and Scopus databases were searched for relevant studies up to April 2023. The quality of included studies was assessed using the QUADAS-2 checklist, and data were extracted. Statistical analysis was performed on 18 studies from 3,993 records, and a diagnostic meta-analysis was conducted. Biomarkers were categorized into four groups based on their type (exosomal miRNAs, exosomal RNAs, alpha-fetoprotein (AFP), and exosomal RNAs+AFP panel), and a meta-analysis was conducted for each category separately. RESULTS: The highest pooled sensitivity was 0.86 for exosomal miRNAs, and exosomal RNAs+AFP had the highest pooled specificity; (0.89). Furthermore, exosomal RNAs+AFP had the highest pooled positive likelihood ratio; (7.55), the highest pooled diagnostic odds ratio (35.96) and the highest pooled area under the curve (0.93). Exosomal miRNAs had the lowest pooled negative likelihood ratio; (0.17). CONCLUSIONS: The diagnostic accuracy of exosomal biomarkers is superior to that of AFP, and combining the two in a panel yields the better results.
| Type de document: | Article |
|---|---|
| Mots-clés libres: | Hepatocellular carcinoma; biomarkers; diagnosis; exosomes; extracellular vesicles; meta-analysis. |
| Centre: | Centre INRS-Institut Armand Frappier |
| Date de dépôt: | 09 déc. 2023 18:04 |
| Dernière modification: | 09 déc. 2023 18:04 |
| URI: | https://espace.inrs.ca/id/eprint/13676 |
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