The end of the reign of a ‘’master regulator’’: A defect in function of the LasR quorum sensing 4 regulator is a common feature of Pseudomonas aeruginosa isolates

Trottier, Mylène; de Oliveira Pereira, Thays; Groleau, Marie-Christine; Hoffman, Lucas R.; Dandekar, Ajai A. et Déziel, Éric ORCID: https://orcid.org/0000-0002-4609-0115 (2023). The end of the reign of a ‘’master regulator’’: A defect in function of the LasR quorum sensing 4 regulator is a common feature of Pseudomonas aeruginosa isolates - . (Soumis)

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Résumé

Pseudomonas aeruginosa, a bacterium known to cause infections in immunocompromised individuals, regulates several of its virulence functions using three interlinked quorum sensing (QS) systems (las, rhl, and pqs). Despite its presumed importance in regulating virulence, dysfunction of the las system regulator LasR occurs frequently in strains isolated from various environments, including clinical infections. This newfound abundance of LasR‐defective strains calls into question existing hypotheses regarding their selection. Indeed, current assumptions concerning factors driving the emergence of LasR deficient isolates and the role of LasR in the QS hierarchy must be reconsidered. Here, we highlight that LasR is not the primary master regulator of QS in all P. aeruginosa genetic backgrounds. We also revisit and complement current knowledge on the ecology of LasR‐dependent QS in P. aeruginosa, review the hypotheses explaining the putative adaptive benefits of selecting against LasR function, and discuss the implications of this renewed understanding.

Type de document:	Article
Mots-clés libres:	-
Centre:	Centre INRS-Institut Armand Frappier
Date de dépôt:	12 sept. 2023 21:04
Dernière modification:	18 sept. 2023 03:40
URI:	https://espace.inrs.ca/id/eprint/13611

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