Occupational heat exposure and prostate cancer risk: A pooled analysis of case-control studies

Hinchliffe, Alice; Alguacil, Juan; Bijoux, Wendy; Kogevinas, Manolis; Menegaux, Florence; Parent, Marie-Élise ORCID: https://orcid.org/0000-0002-4196-3773; Pérez Gomez, Beatriz; Uuksulainen, Sanni et Turner, Michelle C. (2023). Occupational heat exposure and prostate cancer risk: A pooled analysis of case-control studies Environmental Research , vol. 216 , nº Part 2:. pp. 1-8. DOI: 10.1016/j.envres.2022.114592.

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Résumé

Background: Heat exposures occur in many occupations. Heat has been linked to key carcinogenic processes, however, evidence for associations with cancer risk is sparse. We examined potential associations between occupational heat exposure and prostate cancer risk in a multi-country study.

Methods: We analysed a large, pooled dataset of 3142 histologically confirmed prostate cancer cases and 3512 frequency-matched controls from three countries: Canada, France, and Spain. Three exposure indices: ever exposure, lifetime cumulative exposure and duration of exposure, were developed using the Finnish Job-Exposure Matrix, FINJEM, applied to the lifetime occupational history of participants. We estimated odds ratios (ORs) and 95% confidence intervals (CIs), using conditional logistic regression models stratified by 5-year age groups and study, adjusting for potential confounders. Potential interactions with exposure to other occupational agents were also explored.

Results: Overall, we found no association for ever occupational heat exposure (OR 0.97; 95% CI 0.87, 1.09), nor in the highest categories of lifetime cumulative exposure (OR 1.04; 95% CI 0.89, 1.23) or duration (OR 1.03; 95% CI 0.88, 1.22). When using only the Spanish case-control study and a Spanish Job Exposure Matrix (JEM), some weakly elevated ORs were observed.

Conclusions: Findings from this study provide no clear evidence for an association between occupational heat exposure and prostate cancer risk.

Type de document:	Article
Mots-clés libres:	Case-control study; Heat stress; Occupational heat exposure; Pooled analysis; Prostate cancer.
Centre:	Centre INRS-Institut Armand Frappier
Date de dépôt:	09 déc. 2023 18:54
Dernière modification:	09 déc. 2023 18:54
URI:	https://espace.inrs.ca/id/eprint/13398

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