Relationships between Efflux Pumps and Emergence of Heteroresistance: A Comprehensive Study on the Current Findings

Abavisani, Mohammad; Kodori, Mansoor; Akrami, Fariba; Radfar, Ali et Hashemi, Ali (2022). Relationships between Efflux Pumps and Emergence of Heteroresistance: A Comprehensive Study on the Current Findings Canadian Journal of Infectious Diseases & Medical Microbiology , vol. 2022 , nº 3916980. pp. 1-11. DOI: 10.1155/2022/3916980.

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Résumé

Heteroresiatnce (HR) is the type of resistance toward one or more antibiotics appearing as a population of the bacterial load consisting of one or more subpopulations with lower antibiotic susceptibility levels than others. Due to the lack of appropriate diagnosis of HR isolates and their importance in resistance emergence to antibiotics, investigating the origins, emergence factors, and HR inhibitors is critical in combating antibiotic resistance. Efflux pumps (EPs) are bacterial systems that own an influential role in acquiring resistance toward anti-bacterial compounds. Studies on EPs revealed that they can affect HR emergence mechanisms and are competent to be introduced as a suitable bacterial target for diagnostic and therapeutic development in combating HR isolates. This review will consider the relations between EPs and the emergence of HR isolates and discuss their importance in confronting this type of antibiotic resistance.

Type de document:	Article
Mots-clés libres:	-
Centre:	Centre INRS-Institut Armand Frappier
Date de dépôt:	29 déc. 2023 03:44
Dernière modification:	29 déc. 2023 03:44
URI:	https://espace.inrs.ca/id/eprint/13325

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