Corsenac, Philippe; Parent, Marie-Élise 
ORCID: https://orcid.org/0000-0002-4196-3773; Mansaray, Hélène; Benedetti, Andrea; Richard, Hugues; Stäger, Simona ORCID: https://orcid.org/0000-0001-5508-9565 et Rousseau, Marie-Claude ORCID: https://orcid.org/0000-0001-5215-8086
(2022).
Early life Bacillus Calmette-Guerin vaccination and incidence of type 1, type 2, and latent autoimmune diabetes in adulthood
Diabetes & Metabolism
, vol. 48
, nº 3-101337.
pp. 1-9.
DOI: 10.1016/j.diabet.2022.101337.
Résumé
AIMS: Bacillus Calmette-Guerin (BCG) vaccination limits blood sugar elevations and autoimmunity. Previous studies focused on type 1 diabetes among children, despite possible effects on other phenotypes later in life. We studied association between BCG vaccination and type 1, type 2 and latent autoimmune diabetes (LADA) in adulthood. METHODS: A 1970-1974 birth cohort was linked with the BCG vaccination registry and administrative health data of Quebec. 396,118 people aged 22-44 years were followed-up for diabetes mellitus (DM) onset. Incident DM cases were subjects with ≥1 hospitalization or ≥2 physician claims related to DM over a 2-year period. Type 1 diabetes, type 2 diabetes, and LADA cases were individuals with ≥1 reimbursement of insulin, oral antidiabetic agent, or both. Cox proportional regressions were used to estimate hazard ratios (HR), adjusting for potential confounders. RESULTS: Forty-four percent of subjects were BCG vaccinated, 88% of these before age 1. For type 1 diabetes, no association was found before 30 years old, but vaccinated subjects had a lower risk of this phenotype after age 30 (HRadj= 0.65, 95% CI: 0.44-0.95). BCG vaccination was associated with a lower risk of type 2 diabetes (HRadj=0.85, 95% CI: 0.79-0.92), whereas no association was observed for LADA (HRadj=1.30, 95% CI: 0.71-2.38). Results did not differ by sex. CONCLUSIONS: Early life BCG vaccination was associated with lower risks of both type 1 and type 2 diabetes from early to middle adulthood, but not of LADA. Future studies should explore these long-term associations, while distinguishing diabetes phenotypes.
| Type de document: | Article |
|---|---|
| Mots-clés libres: | Adulthood; Bacillus Calmette-Guerin vaccination; Latent autoimmune diabetes in adults; Risk factor; Type 1 diabetes; Type 2 diabetes |
| Centre: | Centre INRS-Institut Armand Frappier |
| Date de dépôt: | 10 juill. 2022 13:57 |
| Dernière modification: | 10 juill. 2022 13:57 |
| URI: | https://espace.inrs.ca/id/eprint/12750 |
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