Vallières, Éric; Mésidor, Miceline; Roy-Gagnon, Marie-Helene; Richard, Hugues et Parent, Marie-Élise 
ORCID: https://orcid.org/0000-0002-4196-3773
(2021).
General and abdominal obesity trajectories across adulthood, and risk of prostate cancer: results from the PROtEuS study, Montreal, Canada
Cancer Causes Control
, vol. 32
, nº 6.
pp. 653-665.
DOI: 10.1007/s10552-021-01419-z.
Résumé
PURPOSE: Greater body fatness is a probable cause of advanced prostate cancer (PCa). Body fat distribution and timing of exposure may be relevant. We investigated associations between body size trajectories and PCa incidence in a population-based case-control study in Montreal, Canada. METHODS: Cases (n = 1,931), aged ≤ 75 years, were diagnosed with PCa in 2005-2009; 1,994 controls were selected from the electoral list. Interviews were conducted to assess body mass index (BMI) and Stunkard's silhouette at ages 20, 40, 50, 60 years, and before interview. Current waist and hip circumferences were measured, and a predictive model estimated waist circumference in the past. BMI and waist circumference trajectories were determined to identify subgroups. Logistic regression estimated odds ratios (OR) and 95% confidence intervals (CI) for the association between anthropometric indicators and PCa. RESULTS: Subjects with a current BMI ≥ 30 kg/m(2) had a lower risk of overall PCa (OR 0.71, 95% CI 0.59-0.85). Associations with adult BMI followed similar trends for less and more aggressive tumors, with stronger inverse relationships in early adulthood. Contrastingly, current waist circumference ≥ 102 cm was associated with elevated risk of high-grade PCa (OR 1.33, 95% CI 1.03-1.71). Men with increasing BMI or waist circumference adult trajectories had a lower risk of PCa, especially low-grade, than those in the normal-stable range. This was especially evident among men in the obese-increase group for BMI and waist circumference. CONCLUSION: Abdominal obesity increased the risk of aggressive PCa. The inverse relationship between body size trajectories and PCa may reflect PSA hemodilution, lower detection, and/or a true etiological effect.
| Type de document: | Article |
|---|---|
| Mots-clés libres: | Body Mass Index; Case–Control Study; Obesity; Prostate Cancer; Trajectories; Waist Circumference; Waist-Hip Ratio |
| Centre: | Centre INRS-Institut Armand Frappier |
| Date de dépôt: | 30 juin 2022 14:06 |
| Dernière modification: | 30 juin 2022 14:06 |
| URI: | https://espace.inrs.ca/id/eprint/12454 |
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