Dépôt numérique

Cross-Sectional Evaluation of Humoral Responses against SARS-CoV-2 Spike

Prévost, Jérémie, Gasser, Romain, Beaudoin-Bussières, Guillaume, Richard, Jonathan, Duerr, Ralf, Laumaea, Annemarie, Anand, Sai Priya, Goyette, Guillaume, Benlarbi, Mehdi, Ding, Shilei, Medjahed, Halima, Lewin, Antoine, Perreault, Josée, Tremblay, Tony, Gendron-Lepage, Gabrielle, Gauthier, Nicolas, Carrier, Marc, Marcoux, Diane, Piché, Alain, Lavoie, Myriam, Benoit, Alexandre, Loungnarath, Vilayvong, Brochu, Gino, Haddad, Elie, Stacey, Hannah D, Miller, Matthew S, Desforges, Marc, Talbot, Pierre J., Gould Maule, Graham T, Côté, Marceline, Therrien, Christian, Serhir, Bouchra, Bazin, Renée, Roger, Michel et Finzi, Andrés . Cross-Sectional Evaluation of Humoral Responses against SARS-CoV-2 Spike In: 36th International Congress, International-Society of Blood Transfusion, 12-16 December 2020, Barcelone, Espagne.

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Background: SARS-CoV-2 is responsible for the coronavirus disease 2019 (COVID-19) pandemic, infecting millions of people and causing hundreds of thousands of deaths. The Spike glycoproteins of SARS-CoV-2 mediate viral entry and are the main targets for neutralizing antibodies.

Aims: Understanding the antibody response directed against SARS-CoV-2 is crucial for the development of vaccine, therapeutic, and public health interventions.

Methods: Here, we perform a cross-sectional study on 106 SARS-CoV-2-infected individuals to evaluate humoral responses against SARS-CoV-2 Spike.

Results: Most infected individuals elicit anti-Spike antibodies within 2 weeks of the onset of symptoms. The levels of receptor binding domain (RBD)-specific immunoglobulin G (IgG) persist over time, and the levels of anti-RBD IgM and IgA decrease after symptom resolution. Some of the elicited antibodies cross-reacted with other human coronaviruses in a genus-restrictive manner. Although most individuals develop neutralizing antibodies within 2 weeks of infection, the level of neutralizing activity is significantly decreased over time.

Summary/Conclusions: Our results highlight the importance of studying the persistence of neutralizing activity upon natural SARS-CoV-2 infection.

Type de document: Document issu d'une conférence ou d'un atelier
Informations complémentaires: Affiche scientifique P-LB-015 Vox Sanguinis (2020) 115 (Suppl. s1):383
Mots-clés libres: -
Centre: Centre INRS-Institut Armand Frappier
Date de dépôt: 14 juill. 2021 15:37
Dernière modification: 14 juill. 2021 15:37
URI: https://espace.inrs.ca/id/eprint/11879

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