Prévost, Jérémie; Gasser, Romain; Beaudoin-Bussières, Guillaume; Richard, Jonathan; Duerr, Ralf; Laumaea, Annemarie; Anand, Sai Priya; Goyette, Guillaume; Benlarbi, Mehdi; Ding, Shilei; Medjahed, Halima; Lewin, Antoine; Perreault, Josée; Tremblay, Tony; Gendron-Lepage, Gabrielle; Gauthier, Nicolas; Carrier, Marc; Marcoux, Diane; Piché, Alain; Lavoie, Myriam; Benoit, Alexandre; Loungnarath, Vilayvong; Brochu, Gino; Haddad, Elie; Stacey, Hannah D; Miller, Matthew S; Desforges, Marc; Talbot, Pierre J.; Gould Maule, Graham T; Côté, Marceline; Therrien, Christian; Serhir, Bouchra; Bazin, Renée; Roger, Michel et Finzi, Andrés . Cross-Sectional Evaluation of Humoral Responses against SARS-CoV-2 Spike In: 36th International Congress, International-Society of Blood Transfusion, 12-16 December 2020, Barcelone, Espagne.
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Background: SARS-CoV-2 is responsible for the coronavirus disease 2019 (COVID-19) pandemic, infecting millions of people and causing hundreds of thousands of deaths. The Spike glycoproteins of SARS-CoV-2 mediate viral entry and are the main targets for neutralizing antibodies.
Aims: Understanding the antibody response directed against SARS-CoV-2 is crucial for the development of vaccine, therapeutic, and public health interventions.
Methods: Here, we perform a cross-sectional study on 106 SARS-CoV-2-infected individuals to evaluate humoral responses against SARS-CoV-2 Spike.
Results: Most infected individuals elicit anti-Spike antibodies within 2 weeks of the onset of symptoms. The levels of receptor binding domain (RBD)-specific immunoglobulin G (IgG) persist over time, and the levels of anti-RBD IgM and IgA decrease after symptom resolution. Some of the elicited antibodies cross-reacted with other human coronaviruses in a genus-restrictive manner. Although most individuals develop neutralizing antibodies within 2 weeks of infection, the level of neutralizing activity is significantly decreased over time.
Summary/Conclusions: Our results highlight the importance of studying the persistence of neutralizing activity upon natural SARS-CoV-2 infection.
| Type de document: | Document issu d'une conférence ou d'un atelier |
|---|---|
| Informations complémentaires: | Affiche scientifique P-LB-015 Vox Sanguinis (2020) 115 (Suppl. s1):383 |
| Mots-clés libres: | - |
| Centre: | Centre INRS-Institut Armand Frappier |
| Date de dépôt: | 14 juill. 2021 15:37 |
| Dernière modification: | 14 juill. 2021 15:37 |
| URI: | https://espace.inrs.ca/id/eprint/11879 |
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